Comparative characteristics of early-onset vs. late-onset advanced colorectal cancer: a nationwide study in China

作者全名：Liu, Hongwei; Xu, Huifang; Liu, Yin; Zhao, Yuqian; Zhang, Xi; Yu, Yanqin; Du, Lingbin; Liu, Yunyong; Wang, Wenjun; Cao, Helu; Ma, Li; Huang, Juanxiu; Cao, Ji; Li, Li; Fan, Yanping; Gu, Xiaofen; Feng, Changyan; Zhu, Qian; Wang, Xiaohui; Du, Jingchang; Zhang, Shaokai; Qiao, Youlin

作者地址：[Liu, Hongwei; Xu, Huifang; Liu, Yin; Zhang, Shaokai; Qiao, Youlin] Zhengzhou Univ, Affiliated Canc Hosp, Dept Canc Epidemiol, Henan Canc Hosp, Zhengzhou 450008, Peoples R China; [Liu, Hongwei; Xu, Huifang; Liu, Yin; Zhang, Shaokai; Qiao, Youlin] Henan Canc Hosp, Zhengzhou 450008, Peoples R China; [Zhao, Yuqian] Univ Elect Sci & Technol China, Sichuan Clin Res Ctr Canc, Sichuan Canc Ctr, Sichuan Canc Hosp & Inst,Affiliated Canc Hosp,Off, Chengdu, Peoples R China; [Zhang, Xi] Peking Univ, Canc Hosp & Inst, Beijing Off Canc Prevent & Control, Minist Educ Beijing,Key Lab Carcinogenesis & Trans, Beijing, Peoples R China; [Yu, Yanqin] Baotou Med Coll, Affiliated Hosp 1, Clin Epidemiol Res Ctr, Dept Dermatol, Baotou, Peoples R China; [Du, Lingbin] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Canc Prevent, Hangzhou, Peoples R China; [Liu, Yunyong] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Off Shenzhen Canc Prevent & Control Ctr,Natl Canc, Shenzhen, Peoples R China; [Liu, Yunyong] Chinese Acad Med Sci & Peking Union Med Coll, Shenzhen Hosp, Shenzhen, Peoples R China; [Wang, Wenjun] Jining Med Univ, Sch Nursing, Jining, Peoples R China; [Cao, Helu] Xinxiang Cent Hosp, Dept Prevent Hlth, Xinxiang, Peoples R China; [Ma, Li] Dalian Med Univ, Publ Hlth Sch, Dalian, Peoples R China; [Huang, Juanxiu] Wuzhou Red Cross Hosp, Dept Gastroenterol, Wuzhou, Peoples R China; [Cao, Ji] Guangxi Med Univ, Affiliated Hosp 1, Dept Canc Prevent & Control Off, Nanning, Guangxi, Peoples R China; [Li, Li] Jinan Univ, Affiliated Hosp 1, Dept Clin Res, Guangzhou, Peoples R China; [Fan, Yanping] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Canc Ctr, State Key Lab Oncol South China, Guangzhou, Peoples R China; [Gu, Xiaofen] Xinjiang Med Univ, Affiliated Tumor Hosp, Dept Student Affairs, Urumqi, Xinjiang, Peoples R China; [Feng, Changyan] Chongqing Univ, Canc Hosp, Chongqing Key Lab Translat Res Canc Metastasis & I, Chongqing, Peoples R China; [Zhu, Qian] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Wang, Xiaohui] Gansu Prov Canc Hosp, Dept Publ Hlth, Lanzhou, Peoples R China; [Du, Jingchang] Chengdu Med Coll, Sch Publ Hlth, Chengdu, Peoples R China; [Qiao, Youlin] Chinese Acad Med Sci & Peking Union Med Coll, Sch Populat Med & Publ Hlth, Ctr Global Hlth, Beijing 100005, Peoples R China

通信作者：Zhang, SK; Qiao, YL (通讯作者)，Zhengzhou Univ, Affiliated Canc Hosp, Dept Canc Epidemiol, Henan Canc Hosp, Zhengzhou 450008, Peoples R China.; Zhang, SK; Qiao, YL (通讯作者)，Henan Canc Hosp, Zhengzhou 450008, Peoples R China.; Qiao, YL (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Sch Populat Med & Publ Hlth, Ctr Global Hlth, Beijing 100005, Peoples R China.

来源：BMC CANCER

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001205444300001

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Early-onset colorectal cancer; Late-onset colorectal cancer; Clinical epidemiology features; Health-related quality of life

摘要：Background The incidence of early-onset colorectal cancer (EOCRC, diagnosed in patients under the age of 50 years) has been increasing around the world. Here, we aimed to systematically identify distinctive features of EOCRC.Methods From 2020 to 2021, we conducted a nationwide survey in 19 hospitals, collecting data on advanced CRC patients' demographics, clinical features, disease knowledge, medical experiences, expenditures, and health-related quality of life (HRQOL). We compared these features between EOCRC and late-onset colorectal cancer (LOCRC, >= 50 years old) groups and analyzed the association between EOCRC and HRQOL using multivariate linear regression.Findings In total, 991 patients with EOCRC and 3581 patients with LOCRC were included. Compared to the LOCRC group, the EOCRC group had higher levels of education, were more informed about the risk factors for CRC, were more likely to have widespread metastases throughout the body, were more inclined to undergo gene testing, and were more likely to opt for targeted therapy, radiotherapy, and chemotherapy. However, HRQOL in the EOCRC group was similar to that of the LOCRC group, and no significant association was observed between EOCRC and HRQOL (beta: -0.753, P value: 0.307).Interpretation In Chinese patients, EOCRC patients had more aggressive features. Despite undergoing more intensified treatments and gene testing, they had similar HRQOL compared with LOCRC. These findings advocate for a more tailored approach to treatment, especially for young CRC patients with advanced TNM stages and metastasis.

基金机构：Beijing LoveBook Cancer Foundation; Merck Serono Co., Ltd

基金资助正文：This work was funded by the Beijing LoveBook Cancer Foundation and Merck Serono Co., Ltd.