Pathological and pharmacological functions of the metabolites of polyunsaturated fatty acids mediated by cyclooxygenases, lipoxygenases, and cytochrome P450s in cancers

作者全名：Meng, Yi-Wen; Liu, Jun-Yan

作者地址：[Meng, Yi-Wen; Liu, Jun-Yan] Chongqing Med Univ, Affiliated Hosp 2, CNTTI Inst Life Sci, Chongqing 400016, Peoples R China; [Meng, Yi-Wen; Liu, Jun-Yan] Chongqing Med Univ, Affiliated Hosp 2, Dept Anesthesia, Chongqing 400016, Peoples R China; [Meng, Yi-Wen; Liu, Jun-Yan] Minist Educ, Basic Med Res & Innovat Ctr Novel Target & Therape, Chongqing 400016, Peoples R China; [Liu, Jun-Yan] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China

通信作者：Liu, JY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, CNTTI Inst Life Sci, Chongqing 400016, Peoples R China.; Liu, JY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Anesthesia, Chongqing 400016, Peoples R China.

来源：PHARMACOLOGY & THERAPEUTICS

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001205901400001

JCR分区：Q1

影响因子：12

年份：2024

卷号：256

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：cancer; cyclooxygenase; cytochrome P450; oxylipins; PUFAs

摘要：Oxylipins have garnered increasing attention because they were consistently shown to play pathological and/or pharmacological roles in the development of multiple cancers. Oxylipins are the metabolites of polyunsaturated fatty acids via both enzymatic and nonenzymatic pathways. The enzymes mediating the metabolism of PUFAs include but not limited to lipoxygenases (LOXs), cyclooxygenases (COXs), and cytochrome P450s (CYPs) pathways, as well as the down -stream enzymes. Here, we systematically summarized the pleiotropic effects of oxylipins in different cancers through pathological and pharmacological aspects, with specific reference to the enzymemediated oxylipins. We discussed the specific roles of oxylipins on cancer onset, growth, invasion, and metastasis, as well as the expression changes in the associated metabolic enzymes and the associated underlying mechanisms. In addition, we also discussed the clinical application and potential of oxylipins and related metabolic enzymes as the targets for cancer prevention and treatment. We found the specific function of most oxylipins in cancers, especially the underlying mechanisms and clinic applications, deserves and needs further investigation. We believe that research on oxylipins will provide not only more therapeutic targets for various cancers but also dietary guidance for both cancer patients and healthy humans. (c) 2024 Elsevier Inc. All rights reserved.

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