Correlational analysis of sarcopenia and multimorbidity among older inpatients

作者全名：Xia, Wenjing; Luo, Kang; Gu, Ziwei; Hu, Jianping; Liu, Xintong; Xiao, Qian

作者地址：[Xia, Wenjing; Luo, Kang; Gu, Ziwei; Hu, Jianping; Liu, Xintong; Xiao, Qian] Chongqing Med Univ, Dept Geriatr, Affiliated Hosp 1, Chongqing 400016, Peoples R China

通信作者：Xiao, Q (通讯作者)，Chongqing Med Univ, Dept Geriatr, Affiliated Hosp 1, Chongqing 400016, Peoples R China.

来源：BMC MUSCULOSKELETAL DISORDERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001206104500004

JCR分区：Q2

影响因子：2.2

年份：2024

卷号：25

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Chronic disease; Comorbidity index; Multimorbidity; Sarcopenia

摘要：Background Sarcopenia and multimorbidity are common in older adults, and most of the available clinical studies have focused on the relationship between specialist disorders and sarcopenia, whereas fewer studies have been conducted on the relationship between sarcopenia and multimorbidity. We therefore wished to explore the relationship between the two.Methods The study subjects were older patients (aged >= 65 years) who were hospitalized at the Department of Geriatrics of the First Affiliated Hospital of Chongqing Medical University between March 2016 and September 2021. Their medical records were collected. Based on the diagnostic criteria of the Asian Sarcopenia Working Group in 2019, the relationship between sarcopenia and multimorbidity was elucidated.Results 1.A total of 651 older patients aged 65 years and above with 2 or more chronic diseases were investigated in this study, 46.4% were suffering from sarcopenia. 2. Analysis of the relationship between the number of chronic diseases and sarcopenia yielded that the risk of sarcopenia with 4-5 chronic diseases was 1.80 times higher than the risk of 2-3 chronic diseases (OR 1.80, 95%CI 0.29-2.50), and the risk of sarcopenia with >= 6 chronic diseases was 5.11 times higher than the risk of 2-3 chronic diseases (OR 5.11, 95% CI 2.97-9.08), which remained statistically significant, after adjusting for relevant factors. 3. The Charlson comorbidity index was associated with skeletal muscle mass index, handgrip strength, and 6-meter walking speed, with scores reaching 5 and above suggesting the possibility of sarcopenia. 4. After adjusting for some covariates among 14 common chronic diseases in older adults, diabetes (OR 3.20, 95% CI 2.01-5.09), cerebrovascular diseases (OR 2.07, 95% CI 1.33-3.22), bone and joint diseases (OR 2.04, 95% CI 1.32-3.14), and malignant tumors (OR 2.65, 95% CI 1.17-6.55) were among those that still a risk factor for the development of sarcopenia.Conclusion In the hospitalized older adults, the more chronic diseases they have, the higher the prevalence of sarcopenia. When the CCI is 5, attention needs to be paid to the occurrence of sarcopenia in hospitalized older adults.

基金机构：First Affiliated Hospital of Chongqing Medical University

基金资助正文：We are grateful for the help and support of the medical staff at the Geriatrics Department of the First Affiliated Hospital of Chongqing Medical University.