Liver injury and prolonged hospitalization as indicators of severity in patients with adenovirus infections

作者全名：Tang, Shi; Qin, Ru; Zhang, Dayong; He, Xiaoyan; Yu, Chaowen; Chen, Dapeng; Li, Xiaoqiang; Liu, Shan

作者地址：[Tang, Shi; Zhang, Dayong; He, Xiaoyan; Yu, Chaowen; Liu, Shan] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, Affiliated Childrens Hosp,Minist Educ,Key Lab Chil, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China; [Qin, Ru; Chen, Dapeng; Li, Xiaoqiang] Med Univ, Affiliated Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Clin Lab Chongqing,Minist Educ,Key Lab Child Dev &, Chongqing 400014, Peoples R China

通信作者：Liu, S (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, Affiliated Childrens Hosp,Minist Educ,Key Lab Chil, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China.

来源：BMC INFECTIOUS DISEASES

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001206346900005

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Hospital stay; IFN-gamma; CD4-Positive T-Lymphocytes; Liver injury; Adenovirus infections

摘要：Background Adenovirus (ADV) is a prevalent infective virus in children, accounting for around 5-10% of all cases of acute respiratory illnesses and 4-15% of pneumonia cases in children younger than five years old. Without treatment, severe ADV pneumonia could result in fatality rates of over 50% in cases of emerging strains or disseminated disease. This study aims to uncover the relationship of clinical indicators with primary ADV infection severity, regarding duration of hospitalization and liver injury.Methods In this retrospective study, we collected and analyzed the medical records of 1151 in-patients who met the inclusion and exclusion criteria. According to duration of hospitalization, all patients were divided into three groups. Then the difference and correlation of clinical indicators with ADV infection were analyzed, and the relationship among liver injury, immune cells and cytokines was evaluated.Results The study revealed that patients with a duration of hospitalization exceeding 14 days had the highest percentage of abnormalities across most indicators. This was in contrast to the patients with a hospitalization duration of either less than or equal to 7 days or between 7 and 14 days. Furthermore, correlation analysis indicated that a longer duration of body temperature of >= 39 degrees C, bilateral lung lobes infiltration detected by X ray, abnormal levels of AST, PaO2, and SPO2, and a lower age were all predictive of longer hospital stays. Furthermore, an elevated AST level and reduced liver synthesis capacity were related with a longer hospital stay and higher ADV copy number. Additionally, AST/ALT was correlated positively with IFN-gamma level and IFN-gamma level was only correlated positively with CD4+ T cells.Conclusions The study provided a set of predicting indicators for longer duration of hospitalization, which responded for primary severe ADV infection, and elucidated the possible reason for prolonged duration of hospitalization attributing to liver injury via higher ADV copy number, IFN-gamma and CD4+ T cells, which suggested the importance of IFN-gamma level and liver function monitoring for the patients with primary severe ADV infection.

基金机构：Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission

基金资助正文：Not applicable.