An application of pirfenidone-loaded, lung-targeted nanoliposomes for treating inflammation and early pulmonary fibrosis in ARDS

作者全名：Li, Sheng; Chen, Wanshi; Zhong, Yuhua; Qi, Di; Tan, Yiwen; Zhang, Renzi; Wang, Daoxin

作者地址：[Li, Sheng; Zhong, Yuhua; Qi, Di; Zhang, Renzi; Wang, Daoxin] Chongqing Med Univ, Affiliated Hosp 2, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Tan, Yiwen] Chongqing Med Univ, Affiliated Hosp 2, Dept Pathol, Chongqing, Peoples R China; [Chen, Wanshi] Chongqing Med Univ, Childrens Hosp, Dept Cardiol, Chongqing, Peoples R China

通信作者：Zhang, RZ; Wang, DX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Resp & Crit Care Med, Chongqing, Peoples R China.

来源：MATERIALS & DESIGN

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001206426300001

JCR分区：Q1

影响因子：7.6

年份：2024

卷号：239

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：ARDS; EndMT; Lung-targeting peptide; Lipid nanoparticles; PFD; Inflammation; Fibrosis

摘要：Acute respiratory distress syndrome (ARDS) is a common critical respiratory disease with a high mortality rate that has been sustained for many years and is caused by a variety of intrapulmonary and extrapulmonary pathogenic factors. However, the effective clinical interventions for ARDS currently in use mainly involve respiratory and organ support therapy, and no effective targeted drug intervention is beneficial for patients with ARDS. In the present study, GALA-PFD-Lip were constructed to reduce lung inflammation, reduce lung oxidative stress, inhibit endothelial-to-mesenchymal transition (EndMT), and reduce early pulmonary fibrosis. We found that GALA-PFD-Lip have efficacious lung targeting activity and biosafety, and the anti-inflammatory and antifibrotic effects of GALA-PFD-Lip are superior to those of pure PFD. These results suggest that GALA-PFD-Lip has good clinical translation potential for the treatment of ARDS-induced pulmonary infections. This study provides new ideas for the treatment of inflammation and for the prevention of early progressive fibrosis that is characteristic of ARDS.

基金机构：National Natural Science Foundation of China [82270091]; Postdoctoral Research Project of Chongqing [185]

基金资助正文：This study was supported by the National Natural Science Foundation of China (Grant no. 82270091) and Postdoctoral Research Project of Chongqing NO.185.