Peripheral CD4<SUP>+</SUP> T cells correlate with response and survival in patients with advanced non-small cell lung cancer receiving chemo-immunotherapy

作者全名：Yang, Xin; Li, Qiao; Zeng, Tianyang

作者地址：[Yang, Xin] Deyang Peoples Hosp, Dept Cardiothorac Surg, Deyang, Sichuan, Peoples R China; [Li, Qiao] Deyang Peoples Hosp, Dept Pathol, Deyang, Sichuan, Peoples R China; [Zeng, Tianyang] Chongqing Med Univ, Dept Thorac Surg, Affiliated Hosp 1, Chongqing, Peoples R China

通信作者：Zeng, TY (通讯作者)，Chongqing Med Univ, Dept Thorac Surg, Affiliated Hosp 1, Chongqing, Peoples R China.

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001206431500001

JCR分区：Q1

影响因子：5.7

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：chemoimmunotherapy; lymphocyte subsets; biomarker; prognosis; non-small cell lung cancer

摘要：Background: The aim of the present study was to explore the potential of peripheral immune cells in predicting the response and prognosis of patients with advanced non-small cell lung cancer (NSCLC) receiving anti-PD-1 immunotherapy and platinum-based chemotherapy. Participants and Methods: We utilized flow cytometry to examine the levels and dynamics of blood immune cells in 79 advanced NSCLC patients treated with the chemoimmunotherapy between December 2019 and January 2022. The pre- and post-treatment blood samples were collected within 3 days prior to the initiation of the first and third cycle of combination treatment, respectively. Progression-free survival (PFS) and overall survival (OS) analyses were conducted using Kaplan-Meier method and Cox regression models. Results: The pre-treatment CD4(+)/Total T cells ratio was significantly higher in responders than non-responders (P < 0.05). The levels of pre-treatment total lymphocytes (P = 0.012), total B lymphocytes (P = 0.025), and NK cells (P = 0.022), and post-treatment NK cells (P = 0.011) and NKT cells (P = 0.035) were significantly associated with OS. Post-treatment CD8(+)/Total T cells ratio was positively correlated with OS (P = 0.038). In multivariate analysis, post-treatment NK cells and post-treatment CD4(+)CD8(+)/Total T cells ratio were negatively associated with OS (hazard ratio [HR] = 10.30, P = 0.038) and PFS (HR = 1.95, P = 0.022), respectively. Notably, significantly positive correlations were observed between CD4(+)/Total T cells ratio and prognosis both before and after treatment (P < 0.05). Conclusion: To summarize, our finding reveals that high CD4(+)/total T cells ratio was associated with favorable response and prognosis, highlighting its potential as a predictive biomarker to guide the selection of likely responders to platinum and anti-PD-1 combination therapy.

基金机构：Chengdu University of Traditional Chinese Medicine10.13039/501100008402

基金资助正文：No Statement Available