Short-term reproductive outcomes analysis and prediction of the modified uterine stent treatment for mild to moderate intrauterine adhesions: experience at a single institution

作者全名：Cao, Chaoxia; Chen, Yinan; Li, Jinjin; Xu, Qianjie; Liu, Xiaoli; Zhao, Ruikun; Jiang, Quanjia; Zhou, Qin

作者地址：[Cao, Chaoxia; Liu, Xiaoli] Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Cao, Chaoxia; Liu, Xiaoli] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing 401147, Peoples R China; [Cao, Chaoxia; Liu, Xiaoli] Chongqing Res Ctr Prevent & Control Maternal & Chi, Chongqing 401147, Peoples R China; [Chen, Yinan] UCL, Sch Math & Phys, Dept Math, Gower St, London WC1E 6AE, England; [Li, Jinjin; Zhao, Ruikun; Zhou, Qin] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Chongqing 400016, Peoples R China; [Xu, Qianjie] Chongqing Med Univ, Sch Publ Hlth, Dept Hlth Stat, Chongqing 400016, Peoples R China; [Jiang, Quanjia] Chongqing Shapingba Matern & Child Healthcare Hosp, Dept Obstet & Gynecol, Chongqing 401331, Peoples R China

通信作者：Zhou, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Chongqing 400016, Peoples R China.

来源：BMC WOMENS HEALTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001207197400002

JCR分区：Q2

影响因子：2.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Intrauterine adhesions; Hysteroscopy; Modified uterine stent; reproductive outcomes; endometrial thickness

摘要：Background To evaluate the efficacy of modified uterine stent in the treatment of mild-to-moderate intrauterine adhesions and explore the relative indicators affecting prognosis prediction. Methods A total of 115 patients with mild-to-moderate intrauterine adhesions received a modified uterine stent placement after hysteroscopy adhesiolysis. The second-look hysteroscopy operated after 3 months surgery, and the third-look hysteroscopy operated after 6 months surgery if necessary. The stent was removed when the cavity shape was repaired, then the reproductive outcomes were followed up one year. Results Menstrual blood volume, endometrial thickness and volume had increased significantly after 3 months surgery. The rates of cavity repaired were 86.96% (100/115) after 3 months surgery and 100% (115/115) after 6 months surgery cumulatively. Endometrial thickness after 3-months surgery was positively associated with uterine cavity shape repaired (P<0.01). The receive operating characteristic (ROC) curve showed the rate of uterine cavity shape repaired predicted by the model was 0.92, based on the endometrial thickness after 3-months surgery. The rate of pregnancy was 86.09% (99/115) in one year, while the rate of miscarriage accounted for 26.26% (26/99). The median time interval between stent removal and subsequent conception was 3 months. It showed adhesion recurrence was the risk factor for subsequent pregnancy (P<0.01). Conclusions A modified uterine stent placement under hysteroscopy was an effective approach for mild-to-moderate intrauterine adhesions, which is easy to operate and worthy for clinical promotion. Endometrial thickness measured by ultrasonography probably has predictive value in adhesion recurrence and subsequent pregnancy.

基金机构：Chongqing Health Commission Research [2021MSXM153]

基金资助正文：This work was supported by Chongqing Health Commission Research (No: 2021MSXM153 to QZ).