The oncogenic role and regulatory mechanism of ACAA2 in human ovarian cancer
作者全名：Leng, Yahui; Tian, Tian; Tang, Bingbing; Ma, Yongqing; Li, Zihang; Shi, Qin; Liu, Jiaqi; Zhou, Yang; Wang, Wenlong; Huang, Chengyang; Zhao, Xuan; Feng, Wenxiao; Liu, Yanni; Liang, Jingyin; Liu, Tianhui; Liu, Song; Ren, Qiulei; Liu, Jiakun; Zhang, Te; Zhou, Junsuo; Huang, Qian; Zhang, Yaling; Yin, Bin; Xu, Yuewen; Liu, Liaoyuan; Shen, Li; Zhao, Hongyan
作者地址：[Leng, Yahui; Tian, Tian; Tang, Bingbing; Ma, Yongqing; Li, Zihang; Shi, Qin; Liu, Jiaqi; Zhou, Yang; Wang, Wenlong; Huang, Chengyang; Feng, Wenxiao; Liu, Yanni; Liang, Jingyin; Liu, Tianhui; Liu, Song; Ren, Qiulei; Liu, Jiakun; Zhang, Te; Zhou, Junsuo; Huang, Qian; Zhang, Yaling; Yin, Bin; Xu, Yuewen; Liu, Liaoyuan; Shen, Li; Zhao, Hongyan] Hubei Univ Med, Sch Basic Med, Shiyan, Peoples R China; [Leng, Yahui; Tian, Tian; Tang, Bingbing; Ma, Yongqing; Li, Zihang; Shi, Qin; Liu, Jiaqi; Zhou, Yang; Wang, Wenlong; Huang, Chengyang; Feng, Wenxiao; Liu, Yanni; Liang, Jingyin; Liu, Tianhui; Liu, Song; Ren, Qiulei; Liu, Jiakun; Zhang, Te; Zhou, Junsuo; Huang, Qian; Zhang, Yaling; Yin, Bin; Xu, Yuewen; Liu, Liaoyuan; Shen, Li; Zhao, Hongyan] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Chongqing, Peoples R China; [Leng, Yahui; Tian, Tian; Tang, Bingbing; Ma, Yongqing; Li, Zihang; Shi, Qin; Liu, Jiaqi; Zhou, Yang; Wang, Wenlong; Huang, Chengyang; Feng, Wenxiao; Liu, Yanni; Liang, Jingyin; Liu, Tianhui; Liu, Song; Ren, Qiulei; Liu, Jiakun; Zhang, Te; Zhou, Junsuo; Huang, Qian; Zhang, Yaling; Yin, Bin; Xu, Yuewen; Liu, Liaoyuan; Shen, Li; Zhao, Hongyan] Hubei Univ Med, Biomed Res Inst, Shiyan, Peoples R China; [Leng, Yahui; Tian, Tian; Tang, Bingbing; Ma, Yongqing; Li, Zihang; Shi, Qin; Liu, Jiaqi; Zhou, Yang; Wang, Wenlong; Huang, Chengyang; Feng, Wenxiao; Liu, Yanni; Liang, Jingyin; Liu, Tianhui; Liu, Song; Ren, Qiulei; Liu, Jiakun; Zhang, Te; Zhou, Junsuo; Huang, Qian; Zhang, Yaling; Yin, Bin; Xu, Yuewen; Liu, Liaoyuan; Shen, Li; Zhao, Hongyan] Hubei Univ Med, Taihe Hosp, Dept Clin Oncol, Shiyan, Peoples R China
通信作者：Shen, L; Zhao, HY (通讯作者)，Hubei Univ Med, Sch Basic Med, Shiyan, Peoples R China.
来源：MOLECULAR CARCINOGENESIS
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:001207274900001
JCR分区：Q2
影响因子：3
年份：2024
卷号：63
期号：7
开始页：1362
结束页：1377
文献类型：Article
关键词：ACAA2; DIXDC1; glycosylation modification; OGT
摘要：Acetyl-CoAacyltransferase2 (ACAA2) is a key enzyme in the fatty acid oxidation pathway that catalyzes the final step of mitochondrial beta oxidation, which plays an important role in fatty acid metabolism. The expression of ACAA2 is closely related to the occurrence and malignant progression of tumors. However, the function of ACAA2 in ovarian cancer is unclear. The expression level and prognostic value of ACAA2 were analyzed by databases. Gain and loss of function were carried out to explore the function of ACAA2 in ovarian cancer. RNA-seq and bioinformatics methods were applied to illustrate the regulatory mechanism of ACAA2. ACAA2 overexpression promoted the growth, proliferation, migration, and invasion of ovarian cancer, and ACAA2 knockdown inhibited the malignant progression of ovarian cancer as well as the ability of subcutaneous tumor formation in nude mice. At the same time, we found that OGT can induce glycosylation modification of ACAA2 and regulate the karyoplasmic distribution of ACAA2. OGT plays a vital role in ovarian cancer as a function of oncogenes. In addition, through RNA-seq sequencing, we found that ACAA2 regulates the expression of DIXDC1. ACAA2 regulated the malignant progression of ovarian cancer through the WNT/beta-Catenin signaling pathway probably. ACAA2 is an oncogene in ovarian cancer and has the potential to be a target for ovarian cancer therapy. The proposed model underlying the roles of ACAA2 in human ovarian cancer image
基金机构：National Natural Science Foundation of China [32001024]; The 67th batch China Postdoctoral Science Foundation [2020M673560XB]; Postdoctoral Natural Science Foundation of Chongqing Science and Technology Bureau [cstc2019jcyj-bshX0129]; Hubei University of Medicine Talent Start-up Fund [2017QDJZR12]; Guiding Project of the Hubei Provincial Health Committee [WJ2019F065]; Key Program of the Hubei Province Education Department Fund [D20222101]; Major Program of the Hubei Provincial Science and Technology Department Fund [2022BCE012]; Guiding Project of the Shiyan Science and Technology Bureau [22Y19]; Innovative Research Program for Graduates of Hubei University of Medicine [JC2022016, JC2022013]
基金资助正文：National Natural Science Foundation of China, Grant/Award Number: 32001024; 67th batch China Postdoctoral Science Foundation, Grant/Award Number: 2020M673560XB; Postdoctoral Natural Science Foundation of Chongqing Science and Technology Bureau, Grant/Award Number: cstc2019jcyj-bshX0129; Hubei University of Medicine Talent Start-up Fund, Grant/Award Number:2017QDJZR12; Guiding Project of the Hubei Provincial Health Committee, Grant/Award Number: WJ2019F065; Key Program of the Hubei Province Education Department Fund, Grant/Award Number:D20222101; Major Program of the Hubei Provincial Science and Technology Department Fund, Grant/Award Number: 2022BCE012; Guiding Project of the Shiyan Science and Technology Bureau, Grant/Award Number: 22Y19; Innovative Research Program for Graduates of Hubei University of Medicine, Grant/Award Numbers: JC2022016, JC2022013
