Kikuchi-Fujimoto disease evolves into lupus encephalopathy characterized by venous sinus thrombosis: a case report

作者全名：Qin, Wenyi; Yang, Shuangshuang; Zhang, Lijuan; Liu, Mengqi; Tian, Jiayu; Yang, Juan; Zhou, Guoqing; Rong, Xiaofeng

作者地址：[Qin, Wenyi; Tian, Jiayu; Yang, Juan; Zhou, Guoqing; Rong, Xiaofeng] Chongqing Med Univ, Dept Rheumatol & Immunol, Dept Integrated Tradit Chinese & Western Med, Affiliated Hosp 1, Chongqing, Peoples R China; [Yang, Shuangshuang] Chongqing Med Univ, Dept Lab, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhang, Lijuan; Liu, Mengqi] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China

通信作者：Qin, WY (通讯作者)，Chongqing Med Univ, Dept Rheumatol & Immunol, Dept Integrated Tradit Chinese & Western Med, Affiliated Hosp 1, Chongqing, Peoples R China.

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001207509000001

JCR分区：Q1

影响因子：5.7

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：neuropsychiatric lupus; venous sinus thrombotic; Kikuchi-Fujimoto disease; necrotizing lymphadenitis; cerebrovascular disease

摘要：Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting illness that can progress to systemic lupus erythematosus (SLE) in approximately 30% of cases. Neurological injuries can occur in both diseases, albeit with distinct presentations. Venous sinus thrombosis is a serious cerebrovascular complication in patients with neuropsychiatric SLE but is rarely observed in patients with KFD. The involvement of various antibodies, particularly antiphospholipid antibodies, can cause vascular endothelial cell injury, resulting in focal cerebral ischemia and intracranial vascular embolism in SLE. However, there are cases in which thrombotic pathology occurs without antiphospholipid antibody positivity, attributed to vascular lesions. In this report, we present a case of KFD and lupus encephalopathy featuring cerebral venous sinus thrombosis, despite the patient being negative for antiphospholipid antibody. We also conducted a comparative analysis of C3 and C4 levels in cerebrospinal fluid (CSF) and peripheral blood, along with the protein ratio in CSF and serum, to elucidate the pathological changes and characteristics of lupus encephalopathy.

基金机构：Scientific application and foundation project of Chongqing Science and Health Joint Project [2022Z Y027210]

基金资助正文：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by the Scientific application and foundation project of Chongqing Science and Health Joint Project (NO.2022Z Y027210).