Pregnancy outcomes and birth defects in offspring following Non-steroidal anti-inflammatory drugs exposure during pregnancy: A systematic review and meta-analysis

作者全名：Chen, Xiaohong; Yang, Yang; Chen, Lin; Wang, Kejing

作者地址：[Chen, Xiaohong; Yang, Yang; Chen, Lin; Wang, Kejing] Chongqing Med Univ, Dept Pharm, Women & Childrens Hosp, Chongqing, Peoples R China; [Chen, Xiaohong; Yang, Yang; Chen, Lin; Wang, Kejing] Chongqing Hlth Ctr Women & Children, Dept Pharm, Chongqing, Peoples R China

通信作者：Chen, L; Wang, KJ (通讯作者)，Chongqing Med Univ, Dept Pharm, Women & Childrens Hosp, Chongqing, Peoples R China.

来源：REPRODUCTIVE TOXICOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001207557100001

JCR分区：Q2

影响因子：3.3

年份：2024

卷号：125

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Non-steroidal anti-inflammatory drugs; Congenital anomalies; Spontaneous abortion; Preterm birth

摘要：There is a high global prevalence of NSAIDs during pregnancy. However, current evidence is largely conflicting regarding the safety of gestational NSAIDs use both for the pregnancy and offspring health. The aim of this study is to systematically review the relationship between NSAIDs use during pregnancy and the risk of adverse pregnancy outcomes and congenital abnormalities. Cohort studies and case control studies on congenital malformations, miscarriage and preterm birth in infants born to mothers who were exposed to NSAIDs during pregnancy were identified via PubMed, Medline, Embase, the Cochrane Library databases and the Reprotox (R) database from inception to 26 March 2021, and updated on 6 April 2023. On the whole, compared with the unexposed group, infants exposed to NSAIDs during early pregnancy showed a 28% increased risk of overall congenital anomalies (OR 1.28, 95%CI 1.16-1.40), and 19% for major birth defects (OR 1.19, 95%CI 1.08-1.30). Contrary to previous beliefs, there appeared to be a trend towards a higher risk of miscarriage among women who were exposed to NSAIDs during pregnancy, but the association was not statistically significant (OR 1.20, 95%CI 0.93-1.55). According to our study findings, the use of NSAIDs by pregnant women has been linked to a higher risk of congenital anomalies and a negative impact on preterm birth. Therefore, we advise pregnant women to carefully consider the potential benefits and risks before using NSAIDs during pregnancy.

基金机构：Chongqing science technology commission of China [Cstc2021jcyj-msxmX1089]; Development Support Program for Future Medical Youth Innovation Teams of Chongqing Medical University [WO208]

基金资助正文：This research was funded by Chongqing science technology commission of China (No: Cstc2021jcyj-msxmX1089) and the Development Support Program for Future Medical Youth Innovation Teams of Chongqing Medical University [WO208] .