Resting-state activity and functional connectivity of insula and postcentral gyrus related to psychological resilience in female depressed patients: A preliminary study
作者全名：Wang, Yuhan; Huang, Jie; Zheng, Hanhan; Tao, Li; Gu, Kaiqi; Xie, Caihong; Cha, Lijun; Chen, Hong; Hu, Hua
作者地址：[Wang, Yuhan; Gu, Kaiqi; Cha, Lijun; Chen, Hong; Hu, Hua] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Huang, Jie] Chongqing Eleventh Peoples Hosp, Dept Psychiat, Chongqing 400038, Peoples R China; [Zheng, Hanhan] Fourth Peoples Hosp Chengdu, Dept Psychiat, Chengdu 610000, Sichuan, Peoples R China; [Tao, Li] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Xie, Caihong] Chongqing Technol & Business Inst, Chongqing 400000, Peoples R China
通信作者：Hu, H (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China.
来源：JOURNAL OF AFFECTIVE DISORDERS
ESI学科分类：PSYCHIATRY/PSYCHOLOGY
WOS号：WOS:001208156500001
JCR分区：Q1
影响因子：4.9
年份：2024
卷号：352
期号：
开始页：509
结束页：516
文献类型：Article
关键词：Psychological resilience; Female depression; rs-fMRI; Insula; Postcentral gyrus
摘要：Background: Psychological resilience is a protective factor of depression. However, the neuroimaging characteristics of the relationship between psychological resilience and brain imaging in depression are not very clear. Our objectives were to explore the brain functional imaging characteristics of different levels of resilience in female patients with depression. Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on 58 female depressed patients. According to the resilience score, participants were divided into three groups: Low resilience (Low-res), Medium resilience (Med-res) and High resilience (High-res). We compared the differences in the amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) among the three groups and correlated psychological resilience with ALFF and FC. Results: According to ALFF, there was a higher activation in RI and RPG in the High-res compared with Med-res and Low-res, but no significant differences between Med-res and Low-res. The FC between the RPG and supramarginal gyrus (SG) in the High-res was significantly stronger than that in the Med-res and the Low-res, and the FC of the Med-res is stronger than that of the Low-res. Both ALFF and FC were positively correlated with the score of resilience. Limitations: The sample size of this study was relatively small and it lacked healthy controls. The results of this study could be considered preliminary. Conclusions: Among female patients with depression, patients with higher psychological resilience had higher resting state activation in the RI and RPG and had a stronger interaction between the RPG and the SG.
基金机构：Chongqing Technology Innovation and Application Demonstration Project [cstc2018jscx-msyb0118]; Chongqing Municipal Health and Family Planning Commission Medical Research Project [2016ZDXM003]
基金资助正文：This work was supported by the Chongqing Technology Innovation and Application Demonstration Project (cstc2018jscx-msyb0118) and the Chongqing Municipal Health and Family Planning Commission Medical Research Project (2016ZDXM003).
