Ferrostatin-1 alleviates liver injury via decreasing ferroptosis following ricin toxin poisoning in rat

作者全名：Lin, Ruijiao; Jia, Zijie; Chen, Hongbing; Xiong, Hongli; Bian, Cunhao; He, Xin; Wei, Bi; Fu, Junfeng; Zhao, Minzhu; Li, Jianbo

作者地址：[Lin, Ruijiao; Jia, Zijie; Chen, Hongbing; Xiong, Hongli; Bian, Cunhao; He, Xin; Wei, Bi; Zhao, Minzhu; Li, Jianbo] Chongqing Med Univ, Dept Forens Med, Chongqing 400016, Peoples R China; [Fu, Junfeng] Chongqing Publ Secur Bur, Criminal Invest Detachment Liangjiang New Area Bra, Chongqing 400016, Peoples R China

通信作者：Zhao, MZ; Li, JB (通讯作者)，Chongqing Med Univ, Dept Forens Med, Chongqing 400016, Peoples R China.

来源：TOXICOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001208461100001

JCR分区：Q1

影响因子：4.8

年份：2024

卷号：503

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Ricin poisoning; Hepatotoxicity; Ferroptosis; Ferrostatin-1

摘要：Ricin is a highly toxic plant toxin that can cause multi -organ failure, especially liver dysfunction, and is a potential bioterrorism agent. Despite the serious public health challenge posed by ricin, effective therapeutic for ricin-induced poisoning is currently unavailable. Therefore, it is important to explore the mechanism of ricin poisoning and develop appropriate treatment protocols accordingly. Previous studies have shown that lipid peroxidation and iron accumulation are associated with ricin poisoning. Ferroptosis is an iron -dependent form of cell death caused by excessive accumulation of lipid peroxide. The role and mechanism of ferroptosis in ricin poisoning are unclear and require further study. We investigated the effect of ferroptosis on ricin-induced liver injury and further elucidated the mechanism. The results showed that ferroptosis occurred in the liver of ricinintoxicated rats, and Ferrostatin-1 could ameliorate hepatic ferroptosis and thus liver injury. Ricin induced liver injury by decreasing hepatic reduced glutathione and the protein level of glutathione peroxidase 4 and Solute Carrier Family 7 Member 11, increasing iron, malondialdehyde and reactive oxygen species, and mitochondrial damage, whereas Ferrostatin-1 pretreatment increased hepatic reduced glutathione and the protein level of glutathione peroxidase 4 and Solute Carrier Family 7 Member 11, decreased iron, malondialdehyde, and reactive oxygen species, and ameliorated mitochondrial damage, thereby alleviated liver injury. These results suggested that ferroptosis exacerbated liver injury after ricin poisoning and that inhibition of ferroptosis may be a novel strategy for the treatment of ricin poisoning.

基金机构：　

基金资助正文：