Overview and new insights of lysine-specific histone demethylase 1 in colorectal cancer: promoting epithelial-mesenchymal transition and stemness features of cancer stem cells

作者全名：Chen, Jiang; Yang, Tao; Xiao, Tianbao; Wang, Ziwei; He, Fan; Bao, Tian-tian; Cao, Yibo

作者地址：[Chen, Jiang; Yang, Tao; Xiao, Tianbao; Bao, Tian-tian; Cao, Yibo] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Anorectal Surg, Guiyang 550001, Guizhou, Peoples R China; [Wang, Ziwei] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Chongqing, Peoples R China; [He, Fan] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Oncol, Guiyang, Guizhou, Peoples R China

通信作者：Chen, J (通讯作者)，Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Anorectal Surg, Guiyang 550001, Guizhou, Peoples R China.

来源：ONCOLOGIE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001208578800001

JCR分区：Q4

影响因子：1.4

年份：2024

卷号：26

期号：3

开始页：369

结束页：377

文献类型：Review

关键词：lysine-specific histone demethylase 1 (LSD1); colorectal cancer; epigenetics; epithelial-mesenchymal transition; cancer stem cells

摘要：Colorectal cancer (CRC) is a common malignant tumor, and research on its pathological mechanism has received increasing attention. Most CRC patients have a poor prognosis, and there is still a lack of effective immunotherapy options. An in-depth exploration of the molecular mechanism of CRC occurrence and development is of great clinical significance for the diagnosis, treatment guidance, and prognosis of CRC. Lysine-specific histone demethylase 1 (LSD1) is highly expressed in CRC, and closely related to the occurrence, invasion, metastasis, and drug resistance of CRC. The histone H3K27 demethylase KDM6A forms an inhibitory complex with LSD1 and other epigenetic regulators, silencing epithelial-mesenchymal transition (EMT) transcription factors and inhibiting EMT-induced cancer stem cells (CSCs) properties. LSD1 is a promising target for CRC therapy, some LSD1 inhibitors are in the experimental stage by blocking its demethylase activity and may benefit CRC patients in the clinical treatment course in the future. This article reviews the latest research progress on the function of LSD1 and its relationship with CRC.

基金机构：Science and Technology Project of Guizhou Province

基金资助正文：No Statement Available