The role of leukocytes in myeloproliferative neoplasm thromboinflammation
作者全名：Liu, Yu; Wang, Yingying; Huang, Gang; Wu, Sanyun; Liu, Xiaoyan; Chen, Shuo; Luo, Ping; Liu, Chang; Zuo, Xuelan
作者地址：[Liu, Yu; Wu, Sanyun; Liu, Xiaoyan; Luo, Ping; Liu, Chang; Zuo, Xuelan] Wuhan Univ, Zhongnan Hosp, Dept Hematol, 169 East Lake Rd, Wuhan 430071, Peoples R China; [Wang, Yingying] Chongqing Med Univ, Coll Basic Med, Dept Immunol, Yixueyuan Rd, Chongqing 400016, Peoples R China; [Huang, Gang] UT Hlth San Antonio, Joe R & Teresa Lozano Long Sch Med, Dept Cell Syst & Anat, Dept Pathol & Lab Med, 8403 Floyd Curl Dr, San Antonio, TX 78229 USA; [Chen, Shuo] Ohio State Univ, Biomed Sci Grad Program, Columbus, OH 43210 USA
通信作者：Zuo, XL (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Hematol, 169 East Lake Rd, Wuhan 430071, Peoples R China.
来源：JOURNAL OF LEUKOCYTE BIOLOGY
ESI学科分类：IMMUNOLOGY
WOS号：WOS:001209860000001
JCR分区：Q2
影响因子：3.6
年份：2024
卷号：115
期号：6
开始页：1020
结束页：1028
文献类型：Review
关键词：inflammation; JAK2-V617F; leukocytes; myeloproliferative neoplasms; thrombosis
摘要：Classic myeloproliferative neoplasms lacking the Philadelphia chromosome are stem cell disorders characterized by the proliferation of myeloid cells in the bone marrow and increased counts of peripheral blood cells. The occurrence of thrombotic events is a common complication in myeloproliferative neoplasms. The heightened levels of cytokines play a substantial role in the morbidity and mortality of these patients, establishing a persistent proinflammatory condition that culminates in thrombosis. The etiology of thrombosis remains intricate and multifaceted, involving blood cells and endothelial dysfunction, the inflammatory state, and the coagulation cascade, leading to hypercoagulability. Leukocytes play a pivotal role in the thromboinflammatory process of myeloproliferative neoplasms by releasing various proinflammatory and prothrombotic factors as well as interacting with other cells, which contributes to the amplification of the clotting cascade and subsequent thrombosis. The correlation between increased leukocyte counts and thrombotic risk has been established. However, there is a need for an accurate biomarker to assess leukocyte activation. Lastly, tailored treatments to address the thrombotic risk in myeloproliferative neoplasms are needed. Therefore, this review aims to summarize the potential mechanisms of leukocyte involvement in myeloproliferative neoplasm thromboinflammation, propose potential biomarkers for leukocyte activation, and discuss promising treatment options for controlling myeloproliferative neoplasm thromboinflammation. Leukocytes play a pivotal role in myeloproliferative neoplasm thromoboinflammation by releasing mediators and/or interacting with other cells, which could be potential treatment targets.
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