Systemic loss of CD36 aggravates NAFLD-related HCC through MEK1/ 2-ERK1/2 signaling pathway

作者全名：Zheng, Enze; Chen, Qianqian; Xiao, Anhua; Luo, Xiaoqing; Lu, Qiannan; Tian, Chuan; Liu, Huan; Zhao, Jinqing; Wei, Li; Yang, Ping; Chen, Yaxi

作者地址：[Zheng, Enze; Chen, Qianqian; Xiao, Anhua; Luo, Xiaoqing; Lu, Qiannan; Tian, Chuan; Liu, Huan; Zhao, Jinqing; Wei, Li; Yang, Ping; Chen, Yaxi] Chongqing Med Univ, Affiliated Hosp 2, Ctr Lipid Res, Chongqing 400016, Peoples R China; [Zheng, Enze; Chen, Qianqian; Xiao, Anhua; Luo, Xiaoqing; Lu, Qiannan; Tian, Chuan; Liu, Huan; Zhao, Jinqing; Wei, Li; Yang, Ping; Chen, Yaxi] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis,Key Lab Mol Biol Infect Dis,M, Dept Infect Dis,Chongqing Key Lab Metab Lipid & Gl, Chongqing 400016, Peoples R China

通信作者：Yang, P; Chen, YX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Ctr Lipid Res, Chongqing 400016, Peoples R China.; Yang, P; Chen, YX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis,Key Lab Mol Biol Infect Dis,M, Dept Infect Dis,Chongqing Key Lab Metab Lipid & Gl, Chongqing 400016, Peoples R China.

来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001211443600001

JCR分区：Q3

影响因子：2.5

年份：2024

卷号：707

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：CD36; Inflammation; NAFLD-Related HCC; MAPK signaling pathway

摘要：Background & aims: CD36, a membrane protein widely present in various tissues, is crucial role in regulating energy metabolism. The rise of HCC as a notable outcome of NAFLD is becoming more apparent. Patients with hereditary CD36 deficiency are at increased risk of NAFLD. However, the impact of CD36 deficiency on NAFLDHCC remains unclear. Methods: Global CD36 knockout mice (CD36KO) and wild type mice (WT) were induced to establish NAFLD-HCC model by N-nitrosodiethylamine (DEN) plus high fat diet (HFD). Transcriptomics was employed to examine genes that were expressed differentially. Results: Compared to WT mice, CD36KO mice showed more severe HFD-induced liver issues and increased tumor malignancy. The MEK1/2-ERK1/2 pathway activation was detected in the liver tissues of CD36KO mice using RNA sequencing and Western blot analysis. Conclusion: Systemic loss of CD36 leaded to the advancement of NAFLD to HCC by causing lipid disorders and metabolic inflammation, a process that involves the activation of MAPK signaling pathway. We found that CD36 contributes significantly to the maintenance of metabolic homeostasis in NAFLD-HCC.

基金机构：National Natural Science Foundation of China [82170586]; Science and Technology Research Program of Chongqing Municipal Education Commission [CSTB2023NSCQ-LZX0001, KJQN202300464]; Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University

基金资助正文：Funding for this study was provided by the National Natural Science Foundation of China (82170586) ; the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. CSTB2023NSCQ-LZX0001, KJQN202300464) ; Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University.