Construction of BaTiO₃-TiO₂ hollow sphere heterojunctions for enhanced microwave dynamic therapy in cancer treatment

作者全名：Chen, Yaodong; Cai, Fangyu; Liu, Yadong; Fan, Wenwen; Wang, Jingjie; Yin, Guolin; Ren, Jiayi; Cao, Jingwei; Fu, Yongming; Chen, Jie

作者地址：[Chen, Yaodong; Fan, Wenwen; Wang, Jingjie; Yin, Guolin; Ren, Jiayi; Cao, Jingwei] Shanxi Med Univ, Hosp 1, Dept Ultrason Imaging, Taiyuan 030001, Peoples R China; [Chen, Jie] Shanxi Med Univ, Hosp 1, Dept Infect Dis, Taiyuan 030001, Peoples R China; [Fu, Yongming] Shanxi Univ, Inst Laser Spect, Sch Phys & Elect Engn, State Key Lab Quantum Opt & Quantum Opt Devices, Taiyuan 030006, Peoples R China; [Cai, Fangyu] Harbin Med Univ, Canc Hosp, Harbin 150040, Peoples R China; [Liu, Yadong] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, State Key Lab Ultrasound Med & Engn, Chongqing 400010, Peoples R China

通信作者：Chen, J (通讯作者)，Shanxi Med Univ, Hosp 1, Dept Infect Dis, Taiyuan 030001, Peoples R China.; Fu, YM (通讯作者)，Shanxi Univ, Inst Laser Spect, Sch Phys & Elect Engn, State Key Lab Quantum Opt & Quantum Opt Devices, Taiyuan 030006, Peoples R China.

来源：PHYSICAL CHEMISTRY CHEMICAL PHYSICS

ESI学科分类：CHEMISTRY

WOS号：WOS:001214515800001

JCR分区：Q1

影响因子：2.9

年份：2024

卷号：26

期号：19

开始页：14131

结束页：14139

文献类型：Article

关键词：　

摘要：Cancer is one of the primary health concerns among humans due to its high incidence rate and lack of effective treatment. Currently, medical techniques to achieve the precise elimination of local cancer lesions with negligible damage to normal tissues are still intensely desired. Herein, we synthesized BaTiO3-TiO2 hollow spheres (BTHSs) for use in microwave dynamic therapy (MWDT) for cancer. Under UV irradiation, BTHSs can mediate the production of multiple reactive oxygen species (ROS), mainly O-1(2), which results in a rapid photocatalytic degradation rate (97%), 1.6-fold that of commercial P25. Importantly, the ROS production process can be triggered by microwaves to effectively execute MWDT for cancer. Under microwave irradiation, BTHSs exhibit a remarkable therapeutic effect and slight cytotoxicity. In terms of mechanism, the enhanced ROS production efficiency of BTHSs can be attributed to their unique hollow structure and the formation of a type-II heterojunction by the incorporation of BaTiO3. The hollow structure increases the availability of active sites and enhances light scattering, while the BaTiO3-TiO2 heterojunction enhances the photocatalytic activity of TiO2 through charge transfer and electron-hole separation. Overall, this study provides important insights into the design and optimization of sensitizers for MWDT applications.

基金机构：China Postdoctoral Science Foundation [82001850]; National Natural Science Foundation of China [2021M691993]; China Postdoctoral Science Foundation [201901D211491]; Shanxi Basic Application Research [2019038]; Scientific Research Project of Shanxi Health Commission [XD1901]; Doctoral Research Project of Shanxi Medical University [YBWRC004]; Research Project of First Hospital of Shanxi Medical University [2112012723387098]; Chongqing Postdoctoral Research Special Funding Project

基金资助正文：This work was supported by the National Natural Science Foundation of China (grant No. 82001850), China Postdoctoral Science Foundation (grant No. 2021M691993), Shanxi Basic Application Research (grant No. 201901D211491), the Scientific Research Project of Shanxi Health Commission (grant No. 2019038), the Doctoral Research Project of Shanxi Medical University (grant No. XD1901), the Research Project of First Hospital of Shanxi Medical University (grant No. YBWRC004), and the Chongqing Postdoctoral Research Special Funding Project (grant No. 2112012723387098).