Epidemiological Characteristics of Human Parainfluenza Viruses Infections - China, 2019-2023

作者全名：Gao, Yixuan; Ma, Yingwei; Feng, Daxing; Zhang, Feng; Wang, Biao; Liu, Xiaoqing; Zhu, Bing; Xie, Hui; Zhao, Linqing; Long, Xiaoru; Chen, Ying; Wang, Bing; Jiang, Jie; Zhu, Zhen; Zhang, Yan; Cui, Aili; Xia, Baicheng; Mao, Naiying

作者地址：[Gao, Yixuan; Jiang, Jie; Zhu, Zhen; Zhang, Yan; Cui, Aili; Xia, Baicheng; Mao, Naiying] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing, Peoples R China; [Ma, Yingwei] Childrens Hosp Changchun, Precis Med Res Ctr, Changchun, Jilin, Peoples R China; [Feng, Daxing] Henan Prov Ctr Dis Control & Prevent, Zhengzhou, Henan, Peoples R China; [Zhang, Feng] Qingdao Municipal Ctr Dis Control & Prevent, Lab Viral Dis, Qingdao, Shandong, Peoples R China; [Wang, Biao] Gansu Prov Ctr Dis Control & Prevent, Virus Lab, Lanzhou, Gansu, Peoples R China; [Liu, Xiaoqing] Jiangxi Prov Ctr Dis Control & Prevent, Nanchang, Jiangxi, Peoples R China; [Zhu, Bing] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Virus Lab, Guangzhou, Guangdong, Peoples R China; [Xie, Hui] Acad Prevent Med, Inst Immunizat & Prevent, Inst TB Control Res & Prevent, Beijing Ctr Dis Prevent & Control, Beijing, Peoples R China; [Zhao, Linqing] Capital Inst Pediat, Lab Virol, Beijing Key Lab Etiol Viral Dis Children, Beijing, Peoples R China; [Long, Xiaoru] Chongqing Med Univ, Childrens Hosp, Dept Infect, Chongqing, Peoples R China; [Chen, Ying] Inner Mongolia Autonomous Reg Comprehens Ctr Dis C, Hohhot, Inner Mongolia, Peoples R China; [Wang, Bing] Shenyang Prefecture Ctr Dis Control & Prevent, Shenyang, Liaoning, Peoples R China

通信作者：Mao, NY (通讯作者)，Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing, Peoples R China.

来源：CHINA CDC WEEKLY

ESI学科分类：　

WOS号：WOS:001214760200001

JCR分区：Q1

影响因子：4.3

年份：2024

卷号：6

期号：12

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要：Introduction : A retrospective study based on sentinel surveillance was conducted in 10 provinciallevel administrative divisions (PLADs) in China to enhance the understanding of the epidemiological characteristics of human parainfluenza viruses (HPIVs). Methods : From January 2019 to June 2023, respiratory specimens were collected from individuals with acute respiratory infections (ARIs) and screened for four HPIVs serotypes and other common respiratory viruses using multiplex real-time polymerase chain reaction (PCR). This study analyzed the association of HPIVs infections with seasonal patterns, geographical distribution, demographic profiles, clinical features, and co -infection status. Results : During the study period, a total of 12,866 ARIs were included. The overall detection rate of HPIVs was 6.15 % , varying from 5.04 % in 2022 to 9.70 % in 2020. The median age of HPIVs-infected patients was 3 years. HPIV2 was more prevalent among individuals aged 5-17 years (42.57 % ), while HPIV4 was more common in those over 65 years (12.24 % ). HPIV3 (54.16 % ) and HPIV1 (27.18 % ) were the predominant serotypes, and their prevalence exhibited significant seasonal fluctuations postcoronavirus disease 2019 (COVID-19) pandemic. The peak of HPIV3 shifted three months later in 2020 compared to 2019 and returned to a summer peak thereafter. Two peaks of HPIV1 were observed in 2021 following the peak of HPIV3. Additionally, coinfections were frequent in HPIVs cases (overall rate: 22.12 % ), with human rhinovirus being the most common co -infecting virus. Conclusions : The prevalence of HPIVs in China was predominantly due to HPIV3 and HPIV1, and their seasonal patterns were altered by pandemic restrictions. Hence, continuous surveillance of HPIVs is essential.

基金机构：National Health Commission Major Public Health Project [ZDGW21-131031103000180005]

基金资助正文：Funding: Supported by the National Health Commission Major Public Health Project (ZDGW21-131031103000180005) .