Exploring the association between multiple factors and urolithiasis: A retrospective study and Mendelian randomization analysis

作者全名：Yin, Kexin; Yin, Zhikang; Liu, Zhenyu; Yao, Junjie; Wu, Yuzhou; Su, Shuai

作者地址：[Yin, Kexin; Wu, Yuzhou] Chongqing Med Univ, Clin Coll 1, Chongqing, Peoples R China; [Yin, Zhikang; Liu, Zhenyu; Yao, Junjie; Su, Shuai] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China; [Liu, Zhenyu] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China

通信作者：Liu, ZY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China.

来源：MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001214832000037

JCR分区：Q2

影响因子：1.3

年份：2024

卷号：103

期号：18

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结束页：　

文献类型：Article

关键词：calcium; Mendelian randomization; stone composition; urolithiasis

摘要：To investigate the relationship between several factors and urinary stone as well as different stone compositions. To guide the diagnosis, treatment, and prevention of urinary stone recurrence. We used bidirectional Mendelian randomization to analyze the causal relationship between hypertension and urinary stones, diabetes and urinary stones, and body mass index (BMI) and urinary stones. We retrospectively analyzed the medical records of patients with urinary stones admitted to a tertiary care hospital in Chongqing, China, from July 2015 to October 2022. Patients were included when they were first diagnosed with urinary stones. The odds ratio of calculi on hypertension estimated by inverse variance weighted was 8.46 (95%CI: 4.00-17.90, P = 2.25 x 10-8). The stone composition analysis showed that there were 3101 (67.02%) mixed, 1322 (28.57%) calcium oxalate monohydrate, 148 (3.20%) anhydrous uric acid, 16 (0.35%) magnesium ammonium phosphate hexahydrate, 11 (0.24%) dicalcium phosphate dihydrate, 10 (0.22%) carbonate apatite, 8 (0.17%) L-cystine, 4 ammonium uric acid (0.09%), and 7 other stone types (0.15%). Mendelian randomization studies have proven that urinary stones may be a potential risk factor for hypertension, while there is no causal relationship between diabetes and stones, BMI, and stones. Our retrospective study has shown that urinary stone components are closely associated with sex, age, hypertension, diabetes, and BMI. It is reasonable to suspect that treating a single stone component is ineffective in preventing recurrence. We also found that the peak incidence of urinary stones was at the most active stage of most people's working lives.

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