Low-Intensity Pulsed Ultrasound: A Physical Stimulus with Immunomodulatory and Anti-inflammatory Potential

作者全名："Liang, Wenxin; Liang, Beibei; Yan, Kaicheng; Zhang, Guanxuanzi; Zhuo, Jiaju; Cai, Yun"

作者地址："[Liang, Wenxin; Liang, Beibei; Yan, Kaicheng; Zhang, Guanxuanzi; Zhuo, Jiaju; Cai, Yun] Chinese Peoples Liberat Army Gen Hosp, Ctr Med Clin Res, Med Supplies Ctr, Dept Pharm, 28 Fu Xing Rd, Beijing 100853, Peoples R China; [Liang, Wenxin; Zhuo, Jiaju] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China"

通信作者："Cai, Y (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Ctr Med Clin Res, Med Supplies Ctr, Dept Pharm, 28 Fu Xing Rd, Beijing 100853, Peoples R China."

来源：ANNALS OF BIOMEDICAL ENGINEERING

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001215029400002

JCR分区：Q2

影响因子：3.8

年份：2024

卷号：52

期号：8

开始页：1955

结束页：1981

文献类型：Review

关键词：Low-intensity pulsed ultrasound; LIPUS; Immunomodulation; Anti-inflammation; Immune

摘要："Ultrasound has expanded into the therapeutic field as a medical imaging and diagnostic technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that plays a vital role in promoting fracture healing, wound repair, immunomodulation, and reducing inflammation. Its anti-inflammatory effects are manifested by decreased pro-inflammatory cytokines and chemokines, accelerated regression of immune cell invasion, and accelerated damage repair. Although the anti-inflammatory mechanism of LIPUS is not very clear, many in vitro and in vivo studies have shown that LIPUS may play its anti-inflammatory role by activating signaling pathways such as integrin/Focal adhesion kinase (FAK)/Phosphatidylinositol 3-kinase (PI3K)/Serine threonine kinase (Akt), Vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS), or inhibiting signaling pathways such as Toll-like receptors (TLRs)/Nuclear factor kappa-B (NF-kappa B) and p38-Mitogen-activated protein kinase (MAPK). As a non-invasive physical therapy, the anti-inflammatory and immunomodulatory effects of LIPUS deserve further exploration."

基金机构：National Natural Science Foundations of China [82073894]; Cultivation Project of PLA General Hospital for Distinguished Young Scientists [2020-JQPY-004]; New Medicine Clinical Research Fund [4246Z512]

基金资助正文："This work was supported by the National Natural Science Foundations of China (82073894), Cultivation Project of PLA General Hospital for Distinguished Young Scientists (2020-JQPY-004), and New Medicine Clinical Research Fund (4246Z512)."