Unraveling the role of CD24 in Hepatocellular carcinoma: Involvement of inactivated Hippo signaling and SOX4-mediated regulation

作者全名：He, Xiaobai; Zhang, Yangyang; Fang, Quan; Sun, Yue; Zheng, Xiaoguang; Fu, Yu; Fang, Weijiao; Yang, Leixiang; Hong, Yeting; Du, Yaoqiang; Wang, Zhen; Chen, Linjie

作者地址：[He, Xiaobai; Fang, Quan; Zheng, Xiaoguang; Fu, Yu; Hong, Yeting; Chen, Linjie] Hangzhou Med Coll, Sch Lab Med & Bioengn, Hangzhou 310053, Peoples R China; [Zhang, Yangyang] Chongqing Med Univ, Dept Clin Lab, Univ Town Hosp, Chongqing, Peoples R China; [He, Xiaobai; Wang, Zhen; Chen, Linjie] Zhejiang Prov Engn Res Ctr Key Technol Diagnost Te, Hangzhou, Chin, Myanmar; [He, Xiaobai; Chen, Linjie] Zhejiang Prov Key Lab Biomarkers & In Vitro Diagno, Hangzhou, Peoples R China; [Du, Yaoqiang; Wang, Zhen] Hangzhou Med Coll, Allergy Ctr, Dept Transfus Med, Minist Educ,Key Lab Lab Med,Zhejiang Prov Peoples, Hangzhou, Peoples R China; [Sun, Yue] Grand Hosp Shuozhou, Blood Transfus Dept, Shuozhou, Peoples R China; [Fang, Weijiao] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Inst Clin Med Res, Hangzhou 310014, Zhejiang, Peoples R China; [Yang, Leixiang] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Genet & Genom Med, Hangzhou, Peoples R China

通信作者：Chen, LJ (通讯作者)，Hangzhou Med Coll, Sch Lab Med & Bioengn, Hangzhou 310053, Peoples R China.; Du, YQ; Wang, Z (通讯作者)，Hangzhou Med Coll, Allergy Ctr, Dept Transfus Med, Minist Educ,Key Lab Lab Med,Zhejiang Prov Peoples, Hangzhou, Peoples R China.

来源：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001215596600001

JCR分区：Q1

影响因子：4.2

年份：2024

卷号：1870

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：Hepatocellular carcinoma; Hippo pathway; SOX4; CD24

摘要：Hepatocellular carcinoma (HCC) is a prevalent type of liver cancer, and CD24 gene is reportedly involved in HCC progression. However, the precise regulatory mechanisms of CD24 in HCC remain unclear. In this study, we established a primary HCC mouse model and observed that CD24, induced by inactivation of the Hippo pathway, was highly expressed in HCC. Using a systematic molecular and genomic approach, we identified the HippoYAP1-SOX4 pathway as the mechanism through which YAP1 induces CD24 upregulation in HCC cells. CD24 knockdown significantly attenuated YAP1 activation-induced HCC. These findings shed light on the link between CD24 and HCC progression, particularly in the Hippo-inactivated subclass of HCC. Therefore, CD24 may serve as a potential target for specific treatment of this HCC subclass.

基金机构：Zhejiang Provincial Natural Science Foundation of China [LQ21H200006, LY20H160046]; Zhejiang Provincial Medical and Health Science and Technology Programs [2021KY132, 2023KY650, 2020KY107]

基金资助正文：This study was financially supported by the Zhejiang Provincial Natural Science Foundation of China (Grant Nos. LQ21H200006, LY20H160046) , and Zhejiang Provincial Medical and Health Science and Technology Programs (2021KY132, 2023KY650, and 2020KY107) .