An ultrasound-triggered injectable sodium alginate scaffold loaded with electrospun microspheres for on-demand drug delivery to accelerate bone defect regeneration

作者全名：Yi, Yin; Song, Jinlin; Zhou, Pengfei; Shu, Yu; Liang, Panpan; Liang, Huimin; Liu, Yanling; Yuan, Xiaoyan; Shan, Xujia; Wu, Xiaohong

作者地址：[Yi, Yin; Song, Jinlin; Zhou, Pengfei; Shu, Yu; Liang, Panpan; Liang, Huimin; Liu, Yanling; Yuan, Xiaoyan; Shan, Xujia; Wu, Xiaohong] Chongqing Med Univ, Stomatol Hosp, 426 Songshibei Rd, Chongqing 401147, Peoples R China; [Yi, Yin; Song, Jinlin; Zhou, Pengfei; Shu, Yu; Liang, Panpan; Liang, Huimin; Liu, Yanling; Yuan, Xiaoyan; Shan, Xujia; Wu, Xiaohong] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Yi, Yin; Song, Jinlin; Zhou, Pengfei; Shu, Yu; Liang, Panpan; Liang, Huimin; Liu, Yanling; Yuan, Xiaoyan; Shan, Xujia; Wu, Xiaohong] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China

通信作者：Wu, XH (通讯作者)，Chongqing Med Univ, Stomatol Hosp, 426 Songshibei Rd, Chongqing 401147, Peoples R China.

来源：CARBOHYDRATE POLYMERS

ESI学科分类：CHEMISTRY

WOS号：WOS:001216082700001

JCR分区：Q1

影响因子：10.7

年份：2024

卷号：334

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Ultrasound -triggered; Electrospun microspheres; Hybrid hydrogel scaffold; On -demand drug release; Bone regeneration

摘要：Biological processes, such as bone defects healing are precisely controlled in both time and space. This spatiotemporal characteristic inspires novel therapeutic strategies. The sustained-release systems including hydrogels are commonly utilized in the treatment of bone defect; however, traditional hydrogels often release drugs at a consistent rate, lacking temporal precision. In this study, a hybrid hydrogel has been developed by using sodium alginate, sucrose acetate isobutyrate, and electrospray microspheres as the base materials, and designed with ultrasound response, and on-demand release properties. Sucrose acetate isobutyrate was added to the hybrid hydrogel to prevent burst release. The network structure of the hybrid hydrogel is formed by the interconnection of Ca2+ with the carboxyl groups of sodium alginate. Notably, when the hybrid hydrogel is exposed to ultrasound, the ionic bond can be broken to promote drug release; when ultrasound is turned off, the release returned to a low-release state. This hybrid hydrogel reveals not only injectability, degradability, and good mechanical properties but also shows multiple responses to ultrasound. And it has good biocompatibility and promotes osteogenesis efficiency in vivo. Thus, this hybrid hydrogel provides a promising therapeutic strategy for the treatment of bone defects.

基金机构：National Natural Science Foundation of China [81970914]

基金资助正文：Illustrations were made using BioRender.com . This work was sup-ported by the National Natural Science Foundation of China (No. 81970914) .