Melanoma extracellular vesicles inhibit tumor growth and metastasis by stimulating CD8 T cells

作者全名：Dan, Yuxi; Ma, Jing; Long, Yuqing; Jiang, Yao; Fang, Liaoqiong; Bai, Jin

作者地址：[Dan, Yuxi; Ma, Jing; Long, Yuqing; Jiang, Yao; Fang, Liaoqiong; Bai, Jin] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; [Dan, Yuxi; Ma, Jing; Long, Yuqing; Jiang, Yao; Bai, Jin] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China; [Fang, Liaoqiong] Natl Engn Res Ctr Ultrasound Med, Chongqing 401121, Peoples R China

通信作者：Fang, LQ; Bai, J (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China.; Bai, J (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China.; Fang, LQ (通讯作者)，Natl Engn Res Ctr Ultrasound Med, Chongqing 401121, Peoples R China.

来源：MOLECULAR IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001216157400001

JCR分区：Q2

影响因子：3.2

年份：2024

卷号：169

期号：　

开始页：78

结束页：85

文献类型：Article

关键词：Extracellular vesicles; Melanoma; CD8 T cells; Dendritic cells

摘要：Tumor cell-derived extracellular vesicles (EVs) play a crucial role in mediating immune responses by carrying and presenting tumor antigens. Here, we suggested that melanoma EVs triggered cytotoxic CD8 T cell-mediated inhibition of tumor growth and metastasis. Our results indicated that immunization of mice with melanoma EVs inhibited melanoma growth and metastasis while increasing CD8 T cells and serum interferon gamma (IFN-gamma) in vivo. In vitro experiments showed that melanoma EV stimulates dendritic cells (DCs) maturation, and mature dendritic cells induce T lymphocyte activation. Thus, tumor cell-derived EVs can generate anti-tumor immunity in a prophylactic setting and may be potential candidates for cell-free tumor vaccines.

基金机构：Chongqing Talent Plan project [cstc2021ycjh-bgzxm0021]

基金资助正文：This work was supported by Chongqing Talent Plan project (cstc2021ycjh-bgzxm0021) .