Prepubertal exposure to polycyclic aromatic hydrocarbons are associated with early pubertal development onset in boys: A longitudinal study

作者全名：Wang, Yujie; Wu, Wenyi; Bravo, Mercedes A.; Liu, Shudan; Xi, Xuan; Zhou, Yuanke; Zhang, Qin; Liu, Qin

作者地址：[Wang, Yujie; Wu, Wenyi; Liu, Shudan; Xi, Xuan; Zhou, Yuanke; Zhang, Qin; Liu, Qin] Chongqing Med Univ, Res Ctr Environm & Human Hlth, Res Ctr Med & Social Dev, Sch Publ Hlth, Chongqing 401331, Peoples R China; [Bravo, Mercedes A.] Duke Univ, Duke Global Hlth Inst, Durham, NC USA; [Liu, Qin] Chongqing Med Univ, Chongqing, Peoples R China

通信作者：Liu, Q (通讯作者)，Chongqing Med Univ, Chongqing, Peoples R China.

来源：JOURNAL OF HAZARDOUS MATERIALS

ESI学科分类：ENGINEERING

WOS号：WOS:001216312900001

JCR分区：Q1

影响因子：12.2

年份：2024

卷号：470

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：PAHs; Boys; Puberty

摘要：Objective: To investigate the effects of polycyclic aromatic hydrocarbons(PAHs) on puberty in boys. Methods: 695 subjects were selected from four primary schools in Chongqing, China. 675 urine samples from these boys were collected four PAH metabolites: 1-hydroxypyrene, 2-hydroxynaphthoic, 2-hydroxyfluorene, and 9-hydroxyphenanthrene. Pubertal development of 695 boys was assessed at follow-up visits starting in December 2015 and occurring every six months thereafter until now, data used in this article ending in June 2021. A total of 12 follow-up visits were performed. Cox proportional hazards regression models were used to analyze the relationship between PAH metabolite concentrations and indicators of pubertal timing. Results: The mean age at puberty onset of testicular volume, facial hair, pubic hair, first ejaculation, and axillary hair in boys was 11.66, 12.43, 12.51, 12.72 and 13.70 years, respectively. Cox proportional hazards regression models showed that boys with moderate level of 1-OHPyr exposure was associated with earlier testicular development (hazard ratio [ HR ] = 1.276, 95% confidence interval [ CI ]: 1.006 -1.619), with moderate level of 2OHNap were at higher risk of early testicular development ( HR =1.273, 95% CI : 1.002 -1.617) and early axillary hair development ( HR = 1.355, 95% CI : 1.040 -1.764), with moderate level of 2-OHFlu was associated with earlier pubic hair development ( HR = 1.256, 95% CI : 1.001 -1.577), with high level of 9-OHPhe were at higher risk of early fisrt ejaculation ( HR = 1.333, 95% CI : 1.005 -1.767) and early facial hair development ( HR = 1.393, 95% CI : 1.059 -1.831). Conclusion: Prepubertal exposure to PAHs may be associated with earlier pubertal development in boys.

基金机构：National Science Fund Project [81973067]; National Youth Science Fund Project [81502825]; Venture & Innovation Support Program for Chongqing Overseas Returnees, China [cx2018105]; Basic and Frontier Research Project of Chongqing Science and Technology Commission [cstc2013jcyjA10001]; CQMU Program for Youth Innovation in Future Medicine [W0054]

基金资助正文：This work was supported by National Science Fund Project [grant number 81973067] , National Youth Science Fund Project [grant number 81502825] , Venture & Innovation Support Program for Chongqing Overseas Returnees, China [grant number cx2018105] , Basic and Frontier Research Project of Chongqing Science and Technology Commission [grant number cstc2013jcyjA10001] , and CQMU Program for Youth Innovation in Future Medicine [grant number W0054] .