Platelet membrane encapsulated curcumin nanomaterial-mediated specific thrombolysis and anti-thrombotic treatment among pregnant women

作者全名：Xu, Lin; Zhou, Yijie; Li, Na; Yang, Anyu; Qi, Hongbo

作者地址：[Xu, Lin; Zhou, Yijie; Li, Na] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet, Chongqing 400016, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Dept Pediat, Chongqing 401147, Peoples R China; [Xu, Lin; Zhou, Yijie; Li, Na; Qi, Hongbo] Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing 400016, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Joint Int Res Lab Reprod & Dev Chinese, Minist Educ, Chongqing 400016, Peoples R China; [Xu, Lin; Zhou, Yijie; Li, Na; Yang, Anyu] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China; [Xu, Lin; Zhou, Yijie] Guiyang Maternal & Child Hlth Care Hosp, Guiyang 550002, Guizhou, Peoples R China

通信作者：Qi, HB (通讯作者)，Chongqing Med Univ, Dept Pediat, Chongqing 401147, Peoples R China.; Qi, HB (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing 400016, Peoples R China.; Qi, HB (通讯作者)，Chongqing Med Univ, Joint Int Res Lab Reprod & Dev Chinese, Minist Educ, Chongqing 400016, Peoples R China.; Yang, AY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China.

来源：BIOMATERIALS SCIENCE

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001217191600001

JCR分区：Q1

影响因子：5.8

年份：2024

卷号：12

期号：12

开始页：3163

结束页：3174

文献类型：Article

关键词：　

摘要：The current treatment for venous thrombosis during pregnancy is ineffective, primarily, due to the unique physiology of pregnant women. Most clinical medications have fetal side effects when they circulate in the body. We first synthesized nanomaterials (Cur-PFP@PC) using poly lactic-co-glycolic acid (PLGA) as the base material, with curcumin (Cur) and perfluoropentane (PFP) as core components. Subsequently, we encapsulated Cur-PFP@PC into the platelet membrane to synthesize P-Cur-PFP@PC. Under ultrasound guidance, in combination with low-intensity focused ultrasound (LIFU), PFP underwent a phase change, resulting in thrombolysis. The generated microbubbles enhanced the signal impact of ultrasound, and P-Cur-PFP@PC showed better performance than Cur-PFP@PC. P-Cur-PFP@PC can target thrombosis treatment, achieve visually and precisely controlled drug release, and repair damaged blood vessels, thus avoiding the adverse effects associated with traditional long-term drug administration. The current treatment of venous thrombus during pregnancy is ineffective, primarily due to the unique physiology of pregnant women.

基金机构：Key Research Program of Chongqing Science and Technology Bureau [CSTB2022TIAD-KPX0156]; Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) [2023GGXM005]; Joint Funds of the National Natural Science Foundation of China [U21A20346]; General Program of Chongqing Science and Technology Bureau [cstc2021jcyj-msxm x0374]; The "111 program" of Ministry of Education P.R.C and State Administration of Foreign Experts Affairs P.R.C

基金资助正文：The research is supported by the Key Research Program of Chongqing Science and Technology Bureau (No. CSTB2022TIAD-KPX0156); Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) (2023GGXM005); Joint Funds of the National Natural Science Foundation of China (No. U21A20346); the General Program of Chongqing Science and Technology Bureau (No. cstc2021jcyj-msxm x0374). The authors thank the support from "111 program" of Ministry of Education P.R.C and State Administration of Foreign Experts Affairs P.R.C.