Impact of hepatic inflammation and fibrosis on the recurrence and long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after hepatectomy

作者全名：Hao, Xiangyong; Xu, Liangliang; Lan, Xiang; Li, Bo; Cai, Hui

作者地址：[Hao, Xiangyong; Xu, Liangliang; Lan, Xiang; Li, Bo] Sichuan Univ, West China Hosp, Dept Gen Surg, Div Liver Surg, Chengdu 610041, Peoples R China; [Hao, Xiangyong; Cai, Hui] Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730000, Peoples R China; [Lan, Xiang] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing 400016, Peoples R China

通信作者：Cai, H (通讯作者)，Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730000, Peoples R China.

来源：BMC CANCER

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001217345900014

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Hepatic inflammation; Hepatic fibrosis; HBV; Hepatectomy; Prognosis

摘要：Background Underlying liver disease is correlated with hepatocellular carcinoma (HCC) development in patients with hepatitis B virus (HBV) infection. However, the impact of hepatic inflammation and fibrosis on the patients' prognoses remains unclear. Methods The clinicopathological data of 638 HBV-infected patients with early-stage HCC between 2017 and 2019 were prospectively collected. Hepatic inflammation and fibrosis were evaluated by experienced pathologists using the Scheuer score system. Survival analysis was analyzed using the Kaplan-Meier analysis. Results Application of the Scheuer scoring system revealed that 50 (7.9%), 274 (42.9%), and 314 (49.2%) patients had minor, intermediate, and severe hepatic inflammation, respectively, and 125 (15.6%), 150 (23.5%), and 363 (56.9%) patients had minor fibrosis, advanced fibrosis, and cirrhosis, respectively. Patients with severe hepatitis tended to have a higher rate of HBeAg positivity, higher HBV-DNA load, elevated alanine aminotransferase (ALT) levels, and a lower proportion of capsule invasion (all Pp < 0.05). There were no significant differences in the recurrence-free and overall survival among the three groups (P = 0.52 and P = 0.66, respectively). Patients with advanced fibrosis or cirrhosis had a higher proportion of HBeAg positivity and thrombocytopenia, higher FIB-4, and larger tumor size compared to those with minor fibrosis (all P < 0.05). Patients with minor, advanced fibrosis, and cirrhosis had similar prognoses after hepatectomy (P = 0.48 and P = 0.70). The multivariate analysis results indicated that neither hepatic inflammation nor fibrosis was an independent predictor associated with prognosis. Conclusions For HBV-related HCC patients receiving antiviral therapy, hepatic inflammation and fibrosis had little impact on the post-hepatectomy prognosis.

基金机构：Gansu Province Youth Innovative Talents Project

基金资助正文：No Statement Available