Advanced navigation technology enables endobronchial brachytherapy for peripheral lung cancer: An old technique plays a new role

作者全名："Li, Yishi; Jiang, Juan; Jiang, Qingfeng; Lu, Wenli; Cui, Haixia; Song, Yanbo; Li, Wencong; Zhang, Tao; Li, Longhao"

作者地址："[Li, Yishi] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Jiang, Juan; Jiang, Qingfeng; Lu, Wenli; Cui, Haixia; Song, Yanbo; Li, Wencong; Zhang, Tao; Li, Longhao] Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Li, LH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：BRACHYTHERAPY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001217780200001

JCR分区：Q3

影响因子：1.9

年份：2024

卷号：23

期号：2

开始页：199

结束页：206

文献类型：Article

关键词：Endobronchial brachytherapy; Navigation technology; Peripheral lung cancer; SBRT

摘要："PURPOSE: To investigate the feasibility of super-selectively endobronchial brachytherapy in the treatment of peripheral lung cancer guided by advanced navigation technology. METHODS AND MATERIALS: Six patients with peripheral lung tumors successfully underwent treatment with super-selectively endobronchial brachytherapy guided by advanced navigation technology following pathway planning and were subsequently followed up to assess survival and treatment-related toxicities. RESULTS: The endobronchial applicators were successfully placed inside the tumors of all patients using advanced navigation techniques according to the pretreatment plan, and brachytherapy was delivered at curative doses after evaluation using radiotherapy planning software. None of the patients showed local progression of the treated lesions during the follow-up for a duration ranging from 11 months to 35 months, with a median follow-up time of 23 months. The patient with the longest follow-up, nearly 3 years, exhibited a stable condition. After undergoing endobronchial brachytherapy, patients predominantly experienced localized fibrosis as indicated. No significant alterations in cardiopulmonary function were detected during the follow-up, and no other adverse effects were found. CONCLUSIONS: The use of endobronchial brachytherapy for the curative treatment of peripheral lung cancers is feasible. Furthermore, the development of novel bronchial navigation techniques has the potential to broaden the application of endobronchial brachytherapy. (c) 2023 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved."

基金机构：Chongqing Science and Health Joint Medical Research Project [2021MSXM318]; CQMU Program for Youth Innovation in Future Medicine [W0119]

基金资助正文：Funding: This work was supported by the Chongqing Science and Health Joint Medical Research Project (No. 2021MSXM318) and the CQMU Program for Youth Innovation in Future Medicine (No. W0119) .