Causal relationship between gestational diabetes and preeclampsia: A bidirectional mendelian randomization analysis

作者全名：Yang, Xiaofeng; Zhong, Qimei; Huang, Mengwei; Li, Li; Tang, Chunyan; Luo, Shujuan; Wang, Lan; Qi, Hongbo

作者地址：[Yang, Xiaofeng; Zhong, Qimei; Li, Li; Tang, Chunyan; Luo, Shujuan; Wang, Lan; Qi, Hongbo] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, 120 Longshan Rd, Chongqing 401147, Peoples R China; [Yang, Xiaofeng; Zhong, Qimei; Li, Li; Tang, Chunyan; Luo, Shujuan; Wang, Lan; Qi, Hongbo] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, 120 Longshan Rd, Chongqing 401147, Peoples R China; [Huang, Mengwei] Chengdu First Peoples Hosp, Dept Obstet & Gynecol, 18 Wanxiang North Rd, Chengdu 610095, Sichuan, Peoples R China

通信作者：Wang, L; Qi, HB (通讯作者)，Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, 120 Longshan Rd, Chongqing 401147, Peoples R China.

来源：DIABETES RESEARCH AND CLINICAL PRACTICE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001219047200001

JCR分区：Q1

影响因子：6.1

年份：2024

卷号：210

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Gestational diabetes mellitus; Preeclampsia; Causal relationship; Mendelian randomization; Genetic instruments

摘要：Aims: The study aimed to explore the potential causal link between gestational diabetes mellitus (GDM) and preeclampsia (PE) using a bidirectional mendelian randomization (MR) analysis. Materials: We conducted a bidirectional MR analysis to investigate the causal relationship between GDM and PE. Data from public genome-wide association studies (GWAS) for GDM and PE were obtained from the FinnGen consortium. Various MR methods were employed, including inverse-variance weighted (IVW), MR-Egger, and sensitivity analyses. Additionally, a knowledge-based approach identified genes underlying this potential connection. Results: The IVW method revealed a lack of significant association between GDM and PE (OR: 1.04, 95 % CI: 0.96-1.14; p = 0.275). Conversely, IVW analysis indicated a causal connection from PE to GDM (OR: 1.14, 95 % CI: 1.06-1.23; p < 0.001). Molecular pathway analysis identified 20 key genes, including ASAP2, central to the PE-GDM relationship. Tissue enrichment analysis showed pertinent gene expression in significant tissues. Moreover, lower ASAP2 expression was detected in PE patients' placentas. Conclusions: Our bidirectional MR analysis offers evidence supporting a causal link between PE and GDM, elucidating their interconnected pathogenesis. Genetic and knowledge-based insights facilitate a deeper comprehension of these complex pregnancy complications.

基金机构：China Postdoctoral Science Foun-dation [2023M740431]

基金资助正文：This study was supported by the China Postdoctoral Science Foun-dation (No: 2023M740431) .