Mechanism of Notch Signaling Pathway in Malignant Progression of Glioblastoma and Targeted Therapy

作者全名：Wang, Shenghao; Gu, Sikuan; Chen, Junfan; Yuan, Zhiqiang; Liang, Ping; Cui, Hongjuan

作者地址：[Wang, Shenghao; Cui, Hongjuan] Southwest Univ, Med Res Inst, Canc Ctr, Chongqing 400716, Peoples R China; [Gu, Sikuan; Chen, Junfan; Yuan, Zhiqiang; Cui, Hongjuan] Southwest Univ, State Key Lab Resource Insects, Chongqing 400716, Peoples R China; [Liang, Ping; Cui, Hongjuan] Chongqing Med Univ, Dept Neurosurg, Childrens Hosp, Chongqing 400014, Peoples R China

通信作者：Cui, HJ (通讯作者)，Southwest Univ, Med Res Inst, Canc Ctr, Chongqing 400716, Peoples R China.; Cui, HJ (通讯作者)，Southwest Univ, State Key Lab Resource Insects, Chongqing 400716, Peoples R China.; Liang, P; Cui, HJ (通讯作者)，Chongqing Med Univ, Dept Neurosurg, Childrens Hosp, Chongqing 400014, Peoples R China.

来源：BIOMOLECULES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001220188500001

JCR分区：Q1

影响因子：4.8

年份：2024

卷号：14

期号：4

开始页：　

结束页：　

文献类型：Review

关键词：glioblastoma; Notch; biological functions; molecular mechanisms; clinical

摘要：Glioblastoma multiforme (GBM) is the most aggressive form of glioma and the most common primary tumor of the central nervous system. Despite significant advances in clinical management strategies and diagnostic techniques for GBM in recent years, it remains a fatal disease. The current standard of care includes surgery, radiation, and chemotherapy, but the five-year survival rate for patients is less than 5%. The search for a more precise diagnosis and earlier intervention remains a critical and urgent challenge in clinical practice. The Notch signaling pathway is a critical signaling system that has been extensively studied in the malignant progression of glioblastoma. This highly conserved signaling cascade is central to a variety of biological processes, including growth, proliferation, self-renewal, migration, apoptosis, and metabolism. In GBM, accumulating data suggest that the Notch signaling pathway is hyperactive and contributes to GBM initiation, progression, and treatment resistance. This review summarizes the biological functions and molecular mechanisms of the Notch signaling pathway in GBM, as well as some clinical advances targeting the Notch signaling pathway in cancer and glioblastoma, highlighting its potential as a focus for novel therapeutic strategies.

基金机构：The pilot program of Southwest University

基金资助正文：No Statement Available