6-Gingerol alleviates ectopic lipid deposition in skeletal muscle by regulating CD36 translocation and mitochondrial function

作者全名：Peng, Ze; Zeng, Yan; Tan, Qi; He, Qifeng; Wang, Shang; Wang, Jianwei

作者地址：[Peng, Ze; Tan, Qi; Wang, Shang; Wang, Jianwei] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing, Peoples R China; [Zeng, Yan; He, Qifeng] Chongqing Med Univ, Coll Basic Med Sci, Chongqing, Peoples R China; [Wang, Jianwei] Chongqing Coll Tradit Chinese Med, Chongqing, Peoples R China

通信作者：Wang, S; Wang, JW (通讯作者)，Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing, Peoples R China.

来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001221336000001

JCR分区：Q3

影响因子：2.5

年份：2024

卷号：708

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：6-Gingerol; Ectopic lipid deposition; O-GlcNAc; CD36 translocation; Mitochondrial

摘要：Ectopic lipid deposition (ELD) and mitochondrial dysfunction are common causes of metabolic disorders in humans. Consuming too much fructose can result in mitochondrial dysfunction and metabolic disorders. 6-Gingerol, the main component of ginger (Zingiber officinale Roscoe), has been proven to alleviate metabolic disorders. This study seeks to examine the effects of 6-gingerol on metabolic disorders caused by fructose and uncover the underlying molecular mechanisms. In this study, the results showed that 6-Gingerol ameliorated highfructose-induced metabolic disorders. Moreover, it inhibited CD36 membrane translocation, increased CD36 expression in the mitochondria, and decreased the O-GlcNAc modification of CD36 and OGT expression in vitro and vivo. In addition, 6-Gingerol enhanced the performance of mitochondria in the skeletal muscle and boosted the respiratory capability of L6 myotubes. This study provides a theoretical basis and new insights for the development of lipid-lowering drugs in clinical practice.

基金机构：National Natural Science Foundation of China [81973653, 81673659]; College of Traditional Chinese Medicine of Chongqing Medical University [:2021-ZDXK-DB02]

基金资助正文：This study was funded by the National Natural Science Foundation of China (81973653 and 81673659) and College of Traditional Chinese Medicine of Chongqing Medical University (No:2021-ZDXK-DB02) .