Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

作者全名：Qin, Leilei; Yang, Shuhao; Zhao, Chen; Yang, Jianye; Li, Feilong; Xu, Zhenghao; Yang, Yaji; Zhou, Haotian; Li, Kainan; Xiong, Chengdong; Huang, Wei; Hu, Ning; Hu, Xulin

作者地址：[Qin, Leilei; Yang, Shuhao; Zhao, Chen; Yang, Jianye; Li, Feilong; Xu, Zhenghao; Yang, Yaji; Zhou, Haotian; Huang, Wei; Hu, Ning] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthopaed, Chongqing 400016, Peoples R China; [Qin, Leilei; Yang, Shuhao; Zhao, Chen; Yang, Jianye; Li, Feilong; Xu, Zhenghao; Yang, Yaji; Zhou, Haotian; Huang, Wei; Hu, Ning] Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China; [Li, Kainan; Hu, Xulin] Chengdu Univ, Clin Med Coll, Chengdu 610081, Sichuan, Peoples R China; [Li, Kainan] Chengdu Univ, Affiliated Hosp, Chengdu 610081, Sichuan, Peoples R China; [Xiong, Chengdong] Univ Chinese Acad Sci, Beijing 101408, Peoples R China; [Hu, Xulin] Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Sichuan, Peoples R China; [Hu, Xulin] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

通信作者：Hu, N (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthopaed, Chongqing 400016, Peoples R China.; Hu, N (通讯作者)，Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China.; Hu, XL (通讯作者)，Chengdu Univ, Clin Med Coll, Chengdu 610081, Sichuan, Peoples R China.; Hu, XL (通讯作者)，Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Sichuan, Peoples R China.; Hu, XL (通讯作者)，Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China.

来源：BONE RESEARCH

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001222588900001

JCR分区：Q1

影响因子：14.3

年份：2024

卷号：12

期号：1

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文献类型：Review

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摘要：Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and impaired restoration of bone deficiencies are major challenges in treatment. Microbes have evolved numerous mechanisms to effectively evade host intrinsic and adaptive immune attacks to persistently localize in the host, such as drug-resistant bacteria, biofilms, persister cells, intracellular bacteria, and small colony variants (SCVs). Moreover, microbial-mediated dysregulation of the bone immune microenvironment impedes the bone regeneration process, leading to impaired bone defect repair. Despite advances in surgical strategies and drug applications for the treatment of bone infections within the last decade, challenges remain in clinical management. The development and application of tissue engineering materials have provided new strategies for the treatment of bone infections, but a comprehensive review of their research progress is lacking. This review discusses the critical pathogenic mechanisms of microbes in the skeletal system and their immunomodulatory effects on bone regeneration, and highlights the prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections. It will inform the development and translation of antimicrobial and bone repair tissue engineering materials for the management of bone infections.

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