Levetiracetam induces severe psychiatric symptoms in people with epilepsy

作者全名：Tao, Kaiyan; Chen, Hongnian; Chen, Yuanyuan; Gu, Yixue; Wang, Xuefeng

作者地址：[Tao, Kaiyan; Chen, Hongnian; Chen, Yuanyuan; Gu, Yixue; Wang, Xuefeng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Neurol, 1 Youyi Rd, Chongqing 400016, Peoples R China

通信作者：Wang, XF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Neurol, 1 Youyi Rd, Chongqing 400016, Peoples R China.

来源：SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001222827400001

JCR分区：Q2

影响因子：2.7

年份：2024

卷号：116

期号：　

开始页：147

结束页：150

文献类型：Article

关键词：Epilepsy; Levetiracetam; Side effects; Psychiatric symptoms

摘要：Background: : Drug-induced psychiatric symptoms are an important cause of treatment failure. Worldwide, levetiracetam has been widely used to treat epilepsy; however, associated psychobehavioral abnormalities have been observed . This study aimed to characterize levetiracetam-induced severe psychiatric symptoms and to propose preventive and therapeutic measures. Methods: : In this retrospective cluster sampling study, psychiatric symptoms of patients who had taken levetiracetam for at least 1 month were analyzed. Results: : 111(7.8%) of the 1,412 included patients exhibited severe psychiatric symptoms. Hallucinations, delusions, aggressive behavior, and agitation were the most common manifestations . Some patients also showed suicidal and self-harm behaviors. These symptoms were mainly controlled by reducing the dose of levetiracetam, stopping the drug, or adding antipsychotic drugs to the treatment regimen. Conclusion: : The severe psychiatric symptoms caused by levetiracetam require special attention.

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