Knockdown of CUEDC1 restrains the growth and migration of hepatocellular carcinoma cells through affecting the T β RI/Smad signaling pathway

作者全名：Wang, Jin; Cao, Zhenglan; Chen, Kehong

作者地址：[Wang, Jin] Chongqing Med Univ, Clin Coll 2, Chongqing 400010, Peoples R China; [Cao, Zhenglan] Jinniu Hosp, Dept Clin Lab, Sichuan Prov Peoples Hosp, Chengdu 610036, Sichuan, Peoples R China; [Chen, Kehong] Chongqing Med Univ, Dept Canc Ctr, Affiliated Hosp 2, Chongqing 400010, Peoples R China

通信作者：Chen, KH (通讯作者)，Chongqing Med Univ, Dept Canc Ctr, Affiliated Hosp 2, Chongqing 400010, Peoples R China.

来源：JOURNAL OF MENS HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001222858700008

JCR分区：Q4

影响因子：0.6

年份：2024

卷号：20

期号：4

开始页：127

结束页：132

文献类型：Article

关键词：CUEDC1; Migration; Hepatocellular carcinoma; The T O RI/Smad signaling pathway

摘要：Hepatocellular carcinoma (HCC), as one usual tumor, and owns the significant mortality rates. The involvement of the coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing 1 ( CUEDC1 ) in cancer progression, either facilitating or inhibiting, has been documented in various cancers. Nevertheless, the regulatory role of CUEDC1 in HCC progression holds unclear. This work aims to elucidate the impact of CUEDC1 on HCC progression. Analysis using the Gene Expression Profiling Interactive Analysis (GEPIA) online database revealed elevated expression of CUEDC1 in liver hepatocellular carcinoma (LIHC) tissues. Subsequently, in HCC cell lines, the elevated CUEDC1 protein expression was confirmed. Silencing CUEDC1 was found to restrain tumor growth in HCC, alongside attenuating cell migration and invasion. Notably, knockdown of CUEDC1 was determined to activate the transforming growth factor - O receptor I (T O RI)/Smad signaling pathway. In conclusion, this study demonstrates that CUEDC1 knockdown restrained the growth and migration of HCC cells under affecting the T O RI/Smad signaling pathway. These findings suggest CUEDC1 could be a helpful target for HCC improvement.

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