A novel combined therapeutic strategy of Nano-EN-IR@Lip mediated photothermal therapy and stem cell inhibition for gastric cancer
作者全名：Yang, Liping; Du, Yan-e; Liao, Fangli; Huang, Tong; Liu, Yadong; Liu, Junzhao; Wang, Can; Zhan, Zhu; Cao, Yang; Wang, Zhigang; Chen, Weixian
作者地址：[Yang, Liping; Du, Yan-e; Liao, Fangli; Chen, Weixian] Chongqing Med Univ, Affiliated Hosp 2, Dept Lab Med, Chongqing 400010, Peoples R China; [Huang, Tong; Liu, Yadong; Liu, Junzhao; Wang, Can; Cao, Yang; Wang, Zhigang] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Zhan, Zhu] Chongqing Med Univ, Dept Infect Dis, Affiliated Hosp 2, Chongqing, Peoples R China
通信作者：Chen, WX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Lab Med, Chongqing 400010, Peoples R China.; Wang, ZG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China.
来源：BIOMEDICINE & PHARMACOTHERAPY
ESI学科分类：PHARMACOLOGY & TOXICOLOGY
WOS号：WOS:001222898300001
JCR分区：Q1
影响因子：6.9
年份：2024
卷号：174
期号：
开始页：
结束页：
文献类型：Article
关键词：Gastric cancer; Cancer stem cell; PTT; EN4; Nanoliposome
摘要：Recurrence and metastasis of gastric cancer is a major therapeutic challenge for treatment. The presence of cancer stem cells (CSCs) is a major obstacle to the success of current cancer therapy, often leading to treatment resistance and tumor recurrence and metastasis. Therefore, it is important to develop effective strategies to eradicate CSCs. In this study, we developed a combined therapeutic strategy of photothermal therapy (PTT) and gastric cancer stem cells (GCSCs) inhibition by successfully synthesizing nanoliposomes loaded with IR780 (photosensitizer) and EN4 (c -Myc inhibitor). The nanocomposites are biocompatible and exhibit superior photoacoustic (PA) imaging properties. Under laser irradiation, IR780-mediated PTT effectively and rapidly killed tumor cells, while EN4 synergistically inhibited the self-renewal and stemness of GCSCs by suppressing the expression and activity of the pluripotent transcription factor c -Myc, preventing the tumor progression of gastric cancer. This Nano-EN-IR@Lip is expected to be a novel clinical nanomedicine for the integration of gastric cancer diagnosis, treatment and prevention.
基金机构：National Natural Science Foundation of China [82172092, 81802447]; China Postdoctoral Science Foundation [2019M663892XB, 2021MD703925, 2022MD723746]; Chongqing Postdoctoral Research Special Funding Project [2112012723387098, 2022CQBSHTB2032]; Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University [kryc-yq-2211]
基金资助正文：This work was supported by the National Natural Science Foundation of China (Grant Nos. 82172092, 81802447) , the China Postdoctoral Science Foundation (Grant No. 2019M663892XB, 2021MD703925, 2022MD723746) , Chongqing Postdoctoral Research Special Funding Project (Grant No. 2112012723387098, 2022CQBSHTB2032) , and also supported by Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University (Grant No. kryc-yq-2211) .
