Poor immune response to inactivated COVID-19 vaccine in patients with hypertension

作者全名：Yang, Lei; Zeng, TingTing; Li, Yang; Guo, Qiao; Jiang, DePeng

作者地址：[Yang, Lei; Li, Yang; Jiang, DePeng] Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China; [Zeng, TingTing] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China; [Guo, Qiao] Chongqing Med Univ, Affiliated Hosp 2, Dept Gen Practice, Chongqing, Peoples R China

通信作者：Jiang, DP (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China.

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001223261300001

JCR分区：Q1

影响因子：3.1

年份：2024

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：COVID-19; safety; immunogenicity; inactivated vaccine; hypertension

摘要：Purpose The safety and efficacy of vaccination in people with hypertension (HTN) is important. There are currently a few data on the immunogenicity and safety of inactivated SARS-CoV-2 vaccinations in hypertension patients. Methods After receiving a two-dose immunization, 94 hypertension adult patients and 74 healthy controls (HCs) in this study, the evaluation included looking at antibodies (Abs) against receptor binding domain (RBD) IgG, SARS-CoV-2 neutralizing antibodies (NAbs), RBD-specific B cells, and memory B cells (MBCs). Results There was no discernible difference in the overall adverse events (AEs) over the course of 7 or 30 days between HTN patients and HCs. HTN patients had lower frequencies of RBD-specific memory B cells and the seropositivity rates and titers of Abs compared with HCs (all, p < 0.05). HTN patients with cardiovascular and cerebrovascular conditions (CCVD) have lower titers of CoV-2 NAb than in HCs. The titers of both Abs in HTN declined gradually over time. Conclusion Inactivated COVID-19 vaccinations were safe in hypertension patients; however humoral immune was limited, especially merged CCVD and declined gradually over time.

基金机构：National Natural Science Foundation of China [81772198]; Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0389]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The authors acknowledge the support of the National Natural Science Foundation of China (81772198) and the Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0389) and supported by the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University.