Primary hyperparathyroidism: predictors of sporadic multi-gland disease

作者全名：Yang, Lu; Jing, Xingguo; Pang, Hua; Guan, Lili; Li, Mengdan

作者地址：[Yang, Lu; Jing, Xingguo; Pang, Hua; Guan, Lili; Li, Mengdan] Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing, Peoples R China

通信作者：Li, MD (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing, Peoples R China.

来源：ENDOCRINE CONNECTIONS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001224186900002

JCR分区：Q3

影响因子：2.6

年份：2024

卷号：13

期号：5

开始页：　

结束页：　

文献类型：Review

关键词：primary hyperparathyroidism; sporadic multiglandular disease; predictors

摘要：In this review, we discuss the definition, prevalence, and etiology of sporadic multiglandular disease (MGD), with an emphasis on its preoperative and intraoperative predictors. Primary hyperparathyroidism (PHPT) is the third-most common endocrine disorder, and multiglandular parathyroid disease (MGD) is a cause of PHPT. Hereditary MGD can be definitively diagnosed with detailed family history and genetic testing, whereas sporadic MGD presents a greater challenge in clinical practice, and parathyroidectomy for MGD is associated with a higher risk of surgical failure than single gland disease (SGD). Therefore, it is crucial to be able to predict the presence of sporadic MGD in a timely manner, either preoperatively or intraoperatively. Various predictive methods cannot accurately identify all cases of sporadic MGD, but they can greatly optimize the management of MGD diagnosis and treatment and optimize the cure rate. Future research will urge us to investigate more integrative predictive models as well as increase our understanding of MGD pathogenesis.

基金机构：Chongqing Medical Scientific Research Project [2021MSXM087]

基金资助正文：This work is supported by the Chongqing Medical Scientific Research Project (2021MSXM087).