[4+2] Cyclization or Lossen Rearrangement: Rhodium-Catalyzed Divergent Synthesis of Carboline Derivatives with Anticancer Activity

作者全名：Lv, Lijie; Zheng, Jia; Xiao, Yijie; Ni, Dan; Luo, Zhangshun; Gao, Yunyun; Wei, Yue; He, Yi; Nie, Shenyou

作者地址：[Lv, Lijie; Zheng, Jia; Xiao, Yijie; Ni, Dan; Luo, Zhangshun; Gao, Yunyun; Wei, Yue; He, Yi; Nie, Shenyou] Inst Life Sci, Minist Educ, Basic Med Res & Innovat Ctr Novel Target & Therape, Chongqing 400016, Peoples R China; [Nie, Shenyou] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400016, Peoples R China

通信作者：He, Y; Nie, SY (通讯作者)，Inst Life Sci, Minist Educ, Basic Med Res & Innovat Ctr Novel Target & Therape, Chongqing 400016, Peoples R China.; Nie, SY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400016, Peoples R China.

来源：ORGANIC LETTERS

ESI学科分类：CHEMISTRY

WOS号：WOS:001225207500001

JCR分区：Q1

影响因子：4.9

年份：2024

卷号：26

期号：20

开始页：4212

结束页：4217

文献类型：Article

关键词：　

摘要：An unusual rhodium-catalyzed C-H activation/Lossen rearrangement/oxa-Michael addition tandem cyclization has been achieved along with a tunable well-known C-H activation/[4 + 2] annulation, leading to regio-, chemo-, and diastereoselective access to diverse pentacyclic alpha-carbolines and beta-carboline-1-one derivatives in moderate to good yields with significant anticancer activity.

基金机构：Research foundation of Program for Youth Innovation in Future Medicine from Chongqing Medical University [W0045]; National Natural Science Foundation of China [22177017]; STI2030-Major Projects [2022ZD0212900]; Innovative Group of Natural Science Foundation of Chongqing [CXQT21016]

基金资助正文：This research project was supported by the research foundation of Program for Youth Innovation in Future Medicine from Chongqing Medical University (W0045), the National Natural Science Foundation of China (22177017), STI2030-Major Projects (2022ZD0212900), and Innovative Group of Natural Science Foundation of Chongqing (CXQT21016).