An overview of the cholesterol metabolism and its proinflammatory role in the development of MASLD

作者全名：Zhang, Linqiang; Shi, Yongqiong; Liang, Bin; Li, Xi

作者地址：[Zhang, Linqiang; Shi, Yongqiong; Li, Xi] Chongqing Med Univ, Inst Life Sci, Sch Basic Med, Chongqing, Peoples R China; [Liang, Bin] Yunnan Univ, Ctr Life Sci, Sch Life Sci, Yunnan Key Lab Cell Metab & Dis, Kunming, Yunnan, Peoples R China; [Zhang, Linqiang; Li, Xi] Chongqing Med Univ, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Liang, Bin] University, Ctr Life Sci, Sch Life Sci, South Sect, East Outer Ring Rd, Kunming 650500, Yunnan, Peoples R China

通信作者：Zhang, LQ; Li, X (通讯作者)，Chongqing Med Univ, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Liang, B (通讯作者)，University, Ctr Life Sci, Sch Life Sci, South Sect, East Outer Ring Rd, Kunming 650500, Yunnan, Peoples R China.

来源：HEPATOLOGY COMMUNICATIONS

ESI学科分类：　

WOS号：WOS:001225920900004

JCR分区：Q1

影响因子：5.6

年份：2024

卷号：8

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要：Cholesterol is an essential lipid molecule in mammalian cells. It is not only involved in the formation of cell membranes but also serves as a raw material for the synthesis of bile acids, vitamin D, and steroid hormones. Additionally, it acts as a covalent modifier of proteins and plays a crucial role in numerous life processes. Generally, the metabolic processes of cholesterol absorption, synthesis, conversion, and efflux are strictly regulated. Excessive accumulation of cholesterol in the body is a risk factor for metabolic diseases such as cardiovascular disease, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD). In this review, we first provide an overview of the discovery of cholesterol and the fundamental process of cholesterol metabolism. We then summarize the relationship between dietary cholesterol intake and the risk of developing MASLD, and also the animal models of MASLD specifically established with a cholesterol-containing diet. In the end, the role of cholesterol-induced inflammation in the initiation and development of MASLD is discussed.

基金机构：Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJQN202200440]

基金资助正文：This work was supported by Scientific and Technological Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202200440).