Dapagliflozin ameliorates myocardial infarction injury through AMPKα-dependent regulation of oxidative stress and apoptosis

作者全名：Peng, Yuce; Guo, Mingyu; Luo, Minghao; Lv, Dingyi; Liao, Ke; Luo, Suxin; Zhang, Bingyu

作者地址：[Peng, Yuce; Guo, Mingyu; Luo, Minghao; Lv, Dingyi; Liao, Ke; Luo, Suxin; Zhang, Bingyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China; [Zhang, Bingyu] East China Normal Univ, Wuhu Hosp, Dept Cardiol, Wuhu, Peoples R China; [Peng, Yuce; Guo, Mingyu; Luo, Minghao; Lv, Dingyi; Liao, Ke; Luo, Suxin] Chongqing Med Univ, Cardiovasc Dis Lab, Chongqing 400016, Peoples R China

通信作者：Luo, SX; Zhang, BY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China.

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001226268900001

JCR分区：Q1

影响因子：3.4

年份：2024

卷号：10

期号：7

开始页：　

结束页：　

文献类型：Article

关键词：Myocardial infarction; Dapagliflozin; Oxidative stress; AMPK alpha; Apoptosis

摘要：Dapagliflozin (DAPA) has been demonstrated to reduce cardiovascular mortality and heart failure hospitalization rates in diabetic patients. However, the mechanism underlying its cardioprotective effect in non-diabetic patients remains unclear. Our study aimed to explore the cardio-protective impact of DAPA on myocardial infarction in non-diabetic mice. We induced myocardial infarction in C57BL/6 mice by ligating the descending branch of the left coronary artery. After surgery, the animals were randomly treated with either saline or DAPA. We employed echocardiography, Western blot analysis, and tissue staining to assess post-infarction myocardial injury. Additionally, we investigated the mechanism of action through cell experiments. Compared to the myocardial infarction group, DAPA treatment significantly attenuated ventricular remodeling and improved cardiac function. By mitigating myocardial oxidative stress and apoptosis, DAPA may activate the AMPK alpha signaling pathway, thereby exerting a protective effect. These findings suggest that DAPA could serve as a novel therapeutic approach for patients with cardiac infarction.

基金机构：National Natural Science Foundation of China [82070238]

基金资助正文：This work was supported by the National Natural Science Foundation of China (82070238) .