Nanofibrous chitin/<i> Andrias</i> <i>davidianus </i>skin secretion bioactive sponges with tunable biodegradation rates for bleeding wounds treatment

作者全名：Zhang, Jiayu; Wang, Qunhao; Sefat, Farshid; Coates, Phil; Zhang, Wei; Zhang, Ximu; Song, Jinlin

作者地址：[Zhang, Jiayu; Zhang, Ximu; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China; [Wang, Qunhao; Zhang, Wei] Sichuan Univ, State Key Lab Polymer Mat Engn, Polymer Res Inst, Chengdu 610065, Peoples R China; [Sefat, Farshid; Coates, Phil] Univ Bradford, Interdisciplinary Res Ctr Polymer Sci & Technol Po, Bradford BD7 1DP, England

通信作者：Zhang, XM; Song, JL (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China.; Zhang, W (通讯作者)，Sichuan Univ, State Key Lab Polymer Mat Engn, Polymer Res Inst, Chengdu 610065, Peoples R China.

来源：CHEMICAL ENGINEERING JOURNAL

ESI学科分类：ENGINEERING

WOS号：WOS:001226671200001

JCR分区：Q1

影响因子：13.3

年份：2024

卷号：488

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Chitin; Skin secretion of Andrias davidianus; Shape-memory; Noncompressible hemorrhage; Osseous wound healing

摘要：Shape-memory sponges offer unique prospects for the treatment of uncontrollable bleeding. However, the development of mechanically robust and bioactive shape-memory hemostatic sponges capable of addressing diverse wound scenarios, including noncompressible hemorrhages and bone bleeding, remains a challenge. Herein, a shape-memory nanofibrous sponge composed of chitin (Ch n ) nanofibers and a bioactive material of skin secretion of Andrias davidianus (SSAD) is fabricated for effective hemorrhage control. The obtained Ch n /SSAD sponge exhibits a series of coveted properties, such as tunable biodegradation rate, high water/blood absorption capacity, rapid shape recovery, as well as procoagulant, antibacterial and pro-osteogenesis abilities. The biomedical efficacy of the Ch n /SSAD sponges was assessed in vivo using rat models of liver-perforation hemorrhage and alveolar bone defect. This innovative shape-memory Ch n /SSAD sponge shows great promise in addressing diverse wound conditions.

基金机构：National Natural Science Foundation of China [32070826, U22A20314]; National Key R & D of Program of China [2022YFC2504200]; Outstanding Youth Fund of Chongqing Natural Science Foundation [CSTB2023NSCQ-JQX0006]; Science and Technology Research Project of Chongqing Education Commission [KJQN202200471]; CQMU Program for Youth Innovation in Future Medicine [W0075]

基金资助正文：This work was financed by the National Natural Science Foundation of China (Grant No. U22A20314) , National Key R & D of Program of China (Grant NO. 2022YFC2504200) , the National Natural Science Foundation of China (32070826) , Outstanding Youth Fund of Chongqing Natural Science Foundation (CSTB2023NSCQ-JQX0006) , Science and Technology Research Project of Chongqing Education Commission (KJQN202200471) , CQMU Program for Youth Innovation in Future Medicine (W0075) .