IFN-α/β/IFN-γ/IL-15 pathways identify GBP1-expressing tumors with an immune-responsive phenotype

作者全名：Wang, Lei; Wei, Yuxuan; Jin, Zheng; Liu, Fangfang; Li, Xuchang; Zhang, Xiao; Bai, Xiumei; Jia, Qingzhu; Zhu, Bo; Chu, Qian

作者地址：[Wang, Lei; Wei, Yuxuan; Liu, Fangfang; Li, Xuchang; Chu, Qian] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, Wuhan 430030, Hubei, Peoples R China; [Jin, Zheng] Chongqing Med Univ, Inst Life Sci, Chongqing 400032, Peoples R China; [Jin, Zheng] GloriousMed Clin Lab Shanghai Co Ltd, Res Inst, Shanghai 201318, Peoples R China; [Zhang, Xiao; Bai, Xiumei] Army Med Univ, Army Hosp 953, Xinqiao Hosp, Shigatse Branch, Shigatse 857000, Peoples R China; [Jia, Qingzhu; Zhu, Bo] Army Med Univ, Xinqiao Hosp, Dept Oncol, Chongqing 400037, Peoples R China; [Jia, Qingzhu; Zhu, Bo] Chongqing Key Lab Immunotherapy, Chongqing 400037, Peoples R China

通信作者：Chu, Q (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, Wuhan 430030, Hubei, Peoples R China.

来源：CLINICAL AND EXPERIMENTAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001227041300001

JCR分区：Q2

影响因子：3.2

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：GBP1; Tumor microenvironment; Immunotherapy; Biomarker

摘要：Immunotherapy is widely used in cancer treatment; however, only a subset of patients responds well to it. Significant efforts have been made to identify patients who will benefit from immunotherapy. Successful anti-tumor immunity depends on an intact cancer-immunity cycle, especially long-lasting CD8+ T-cell responses. Interferon (IFN)-alpha/beta/IFN-gamma/interleukin (IL)-15 pathways have been reported to be involved in the development of CD8+ T cells. And these pathways may predict responses to immunotherapy. Herein, we aimed to analyze multiple public databases to investigate whether IFN-alpha/beta/IFN-gamma/IL-15 pathways could be used to predict the response to immunotherapy. Results showed that IFN-alpha/beta/IFN-gamma/IL-15 pathways could efficiently predict immunotherapy response, and guanylate-binding protein 1 (GBP1) could represent the IFN-alpha/beta/IFN-gamma/IL-15 pathways. In public and private cohorts, we further demonstrated that GBP1 could efficiently predict the response to immunotherapy. Functionally, GBP1 was mainly expressed in macrophages and strongly correlated with chemokines involved in T-cell migration. Therefore, our study comprehensively investigated the potential role of GBP1 in immunotherapy, which could serve as a novel biomarker for immunotherapy and a target for drug development.

基金机构：National Natural Science Foundation of China

基金资助正文：No Statement Available