The status of knowledge on migraines: The role of microglia

作者全名：He, Wei; Wang, Yanyun; Zhang, Yixin; Zhang, Yinan; Zhou, Jiying

作者地址：[He, Wei; Zhang, Yinan] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Branch 1, Chongqing, Peoples R China; [Wang, Yanyun; Zhang, Yixin; Zhou, Jiying] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1st You Yi Rd, Chongqing 400016, Peoples R China

通信作者：Zhou, JY (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1st You Yi Rd, Chongqing 400016, Peoples R China.

来源：JOURNAL OF NEUROIMMUNOLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001227130500001

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：381

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Microglia; Migraine; Cortical spreading depression; Neuroinflammation; Chronic headache

摘要：Migraines are a considerable social problem and economic burden worldwide. Current acute treatments are based on inhibiting meningeal neurogenic inflammation which has poor results in some patients, whereas the site of action of prophylactic medicines are unknown; therefore, exploring new treatment mechanisms and methods is increasingly needed. Recent evidence suggests that microglia and microglia-mediated neuroinflammation are important in migraine pathogenesis. In the cortical spreading depression (CSD) migraine model, microglia were activated after multiple CSD stimulations, suggesting that microglial activation may be associated with recurrent attacks of migraine with aura. In the nitroglycerin-induced chronic migraine model, the microglial response to extracellular stimuli leads to the activation of surface purine receptors P2X4 , P2X7 , P2Y12, which mediate signal transduction through intracellular signalling cascades, such as the BDNF/TrkB, NLRP3/IL-1 beta and RhoA/ ROCK signalling pathways, and release inflammatory mediators and cytokines that enhance pain by increasing the excitability of nearby neurons. Inhibition of the expression or function of these microglial receptors and pathways inhibits the abnormal excitability of TNC (trigeminal nucleus caudalis) neurons and intracranial as well as extracranial hyperalgesia in migraine animal models. These findings suggest that microglia may be central in migraine recurrent attacks and a potential target for the treatment of chronic headaches.

基金机构：National Natural Science Foundation of China [81971063]

基金资助正文：<B>Funding</B> This work was supported by the National Natural Science Foundation of China (No. 81971063) .