Achieving NPVR ≥ 80% as technical success of high-intensity focused ultrasound ablation for uterine fibroids: a cohort study

作者全名：Li, Shuang; Yang, Meijie; Yu, Jingwen; Ma, Wangwa; Deng, Yongbin; Hu, Liang; Chen, Jin-Yun

作者地址：[Li, Shuang; Yu, Jingwen; Ma, Wangwa; Hu, Liang; Chen, Jin-Yun] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Med Coll Rd, Chongqing 400016, Peoples R China; [Yang, Meijie] Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China; [Deng, Yongbin] Chongqing Haifu Hosp, Chongqing 401121, Peoples R China; [Hu, Liang; Chen, Jin-Yun] Chongqing Med Univ, Affiliated Hosp 1, Ultrasound Ablat Ctr, Chongqing 400042, Peoples R China

通信作者：Chen, JY (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Med Coll Rd, Chongqing 400016, Peoples R China.; Chen, JY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Ultrasound Ablat Ctr, Chongqing 400042, Peoples R China.

来源：BMC WOMENS HEALTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001227229000004

JCR分区：Q2

影响因子：2.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：High-intensity focused ultrasound (HIFU); Uterine fibroids; Nonperfusion volume ratio (NPVR); Ablation; Re-intervention

摘要：Objective To report the long-term re-intervention of patients with uterine fibroids after ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation and to analyse the influencing factors of re-intervention in patients in the NPVR >= 80% group. Materials and methods Patients with a single uterine fibroid who underwent USgHIFU at our hospital from January 2012 to December 2019 were enrolled. The patients were divided into four groups according to different nonperfusion volume ratio (NPVR). Kaplan-Meier survival curve was used to analyse long-term re-intervention in different NPVR groups, and Cox regression was used to analyse the influencing factors of re-intervention in the NPVR >= 80% group. Main results A total of 1,257 patients were enrolled, of whom 920 were successfully followed up. The median follow-up time was 88 months, and the median NPVR was 85.0%. The cumulative re-intervention rates at 1, 3, 5, 8 and 10 years after USgHIFU were 3.4%, 11.8%, 16.8%, 22.6% and 24.1%, respectively. The 10-year cumulative re-intervention rate was 37.3% in the NPVR < 70% group, 31.0% in the NPVR 70-79% group, 18.2% in the NPVR 80-89% group and 17.8% in the NPVR >= 90% group (P < 0.05). However, no difference was found between the group of NPVR 80-89% and the group of NPVR >= 90% (P = 0.499). Age of patients and signal intensity on T-2-weighted imaging (T2WI) of tumours were found to be independent risk factors for long-term re-intervention in the NPVR >= 80% group. A younger age and greater signal intensity on T2W images corresponded to a greater risk of re-intervention. Conclusion USgHIFU, an alternative treatment for uterine fibroids, has reliable long-term efficacy. NPVR >= 80% can be used as a sign of technical success, which can reduce re-intervention rates. However, an important step is to communicate with patients in combination with the age of patients and the signal intensity on T2WI of fibroids.

基金机构：Science and Technology Research Program of Chongqing Municipal Education Commission

基金资助正文：No Statement Available