Effectiveness and safety of vedolizumab and infliximab in biologic-na?ve patients with moderate-to-severe ulcerative colitis: A multicenter, retrospective cohort study

作者全名：Meng, Rui Ping; Huang, Bao Bao; Wei, Yan Ling; Lyu, Lin; Yang, Huan; Liu, Cheng; Zhou, Hong Li; Liao, Xi Ping; Zhou, Jian Yun; Xie, Xia

作者地址：[Meng, Rui Ping; Huang, Bao Bao; Yang, Huan; Liu, Cheng; Zhou, Hong Li; Liao, Xi Ping; Zhou, Jian Yun; Xie, Xia] Army Med Univ, Xinqiao Hosp, Dept Gastroenterol, 83 Xinqiao Zheng St, Chongqing 400037, Peoples R China; [Wei, Yan Ling] Army Med Univ, Daping Hosp, Dept Gastroenterol, Chongqing, Peoples R China; [Lyu, Lin] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 2, Chongqing, Peoples R China

通信作者：Zhou, JY; Xie, X (通讯作者)，Army Med Univ, Xinqiao Hosp, Dept Gastroenterol, 83 Xinqiao Zheng St, Chongqing 400037, Peoples R China.

来源：JOURNAL OF DIGESTIVE DISEASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001227589700001

JCR分区：Q3

影响因子：2.3

年份：2024

卷号：25

期号：4

开始页：230

结束页：237

文献类型：Article

关键词：effectiveness; infliximab; safety; vedolizumab; ulcerative colitis

摘要：Objectives: We conducted this multicenter, retrospective cohort study aiming to evaluate the effectiveness and safety of vedolizumab (VDZ) and infliximab (IFX) in biologic-na & iuml;ve patients with moderate-to-severe ulcerative colitis (UC). Methods: Biologic-na & iuml;ve patients with moderate-to-severe UC who were treated with IFX or VDZ for at least 14 weeks at three tertiary hospitals in southwest China between January 2021 and January 2023 were retrospectively included. Efficacy of the biologics was evaluated based on the steroid-free clinical remission rate, clinical remission rate, and mucosal healing rate at Weeks 14 and 52. Adverse events related to biologic use were recorded. Results: Altogether 122 biologic-na & iuml;ve patients with moderate-to-severe UC were included. No marked differences in the steroid-free clinical remission rate and clinical remission rate were observed between the two groups at Week 14 or Week 52 (P > 0.05). The VDZ group exhibited a higher mucosal healing rate at Week 14 compared to the IFX group (33.3% vs 16.9%, P = 0.036), while that at Week 52 did not differ between the two groups (65.6% vs 47.1%, P = 0.098). There was no statistically significant difference in the rate of adverse events between the two groups (P = 0.071). Conclusion: VDZ and IFX showed comparable clinical efficacy and safety profiles and can be used as viable first-line therapeutic options for biologic-na & iuml;ve patients with moderate-to-severe UC.

基金机构：Cheng LIU

基金资助正文：No Statement Availabler No Statement Available