Anthocyanins prevent the development and progression of urethane-induced lung cancer by regulating energy metabolism in mice

作者全名：Luo, Han; Gao, Mengyuan; Lu, Hong; Chen, Qianyao; Lian, Xuemei

作者地址：[Luo, Han; Gao, Mengyuan; Lu, Hong; Chen, Qianyao; Lian, Xuemei] Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Chongqing, Peoples R China; [Luo, Han; Gao, Mengyuan; Lu, Hong; Chen, Qianyao; Lian, Xuemei] Chongqing Med Univ, Ctr Lipid Res, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing, Peoples R China; [Lian, Xuemei] Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Key Lab Mol Biol Infect Dis,Minist Educ, Chongqing, Peoples R China

通信作者：Lian, XM (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Key Lab Mol Biol Infect Dis,Minist Educ, Chongqing, Peoples R China.

来源：FOOD & NUTRITION RESEARCH

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001227810000001

JCR分区：Q2

影响因子：3.5

年份：2024

卷号：68

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：anthocyanin; lung cancer; energy metabolism

摘要：Anthocyanin (ACN) is a natural antioxidant with multiple biological activities, and the aim of this study was to evaluate the protective effect of ACN on the development and progression of lung cancer and to further explore its possible mechanism of action. In vivo, we fed C57BL/6J mice a 0.5%ACN diet or a control diet to observe their effects on the development and progression of urethane-induced lung cancer. In vitro, multiple lung cancer cell lines were used to investigate the effects of C3G on cell viability. The results showed a reduction in lung tumor burden and downregulation of oxidative phosphorylation and fatty acid degradation pathways in lung tissue of urethane-administrated ACN-fed mice compared with control diet-fed mice. In vitro, cyanidin-3-O-glucoside chloride (C3G) intervention treatment significantly inhibited proliferation and apoptosis of A549 cells. This process is likely due to the modulation of AMPK/mTOR signaling pathway by C3G to regulate cellular fatty acid metabolism and reduce intracellular lipid accumulation which affects the growth of lung cancer cells. These results suggest that ACN can inhibit the development and progression of urethane-induced lung tumors and alter the lipid metabolism of tumors in C57BL/6J mice.

基金机构：Future Medical Youth Innovation Team Development Support Program of Chongqing Medical University [W0085]

基金资助正文：The authors declare that they have no conflicts of interest with the contents of this article. This work was supported by the Future Medical Youth Innovation Team Development Support Program of Chongqing Medical University (W0085).