Current status, challenges and prospects of antifouling materials for oncology applications

作者全名：Zhang, Yingfeng; Sun, Congcong

作者地址：[Zhang, Yingfeng; Sun, Congcong] Univ Town Hosp, Chongqing Med Univ, Chongqing, Peoples R China

通信作者：Sun, CC (通讯作者)，Univ Town Hosp, Chongqing Med Univ, Chongqing, Peoples R China.

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001228275800001

JCR分区：Q2

影响因子：3.5

年份：2024

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：antifouling materials; cancers; targeted diagnostics and therapy; challenges; application status

摘要：Targeted therapy has become crucial to modern translational science, offering a remedy to conventional drug delivery challenges. Conventional drug delivery systems encountered challenges related to solubility, prolonged release, and inadequate drug penetration at the target region, such as a tumor. Several formulations, such as liposomes, polymers, and dendrimers, have been successful in advancing to clinical trials with the goal of improving the drug's pharmacokinetics and biodistribution. Various stealth coatings, including hydrophilic polymers such as PEG, chitosan, and polyacrylamides, can form a protective layer over nanoparticles, preventing aggregation, opsonization, and immune system detection. As a result, they are classified under the Generally Recognized as Safe (GRAS) category. Serum, a biological sample, has a complex composition. Non-specific adsorption of chemicals onto an electrode can lead to fouling, impacting the sensitivity and accuracy of focused diagnostics and therapies. Various anti-fouling materials and procedures have been developed to minimize the impact of fouling on specific diagnoses and therapies, leading to significant advancements in recent decades. This study provides a detailed analysis of current methodologies using surface modifications that leverage the antifouling properties of polymers, peptides, proteins, and cell membranes for advanced targeted diagnostics and therapy in cancer treatment. In conclusion, we examine the significant obstacles encountered by present technologies and the possible avenues for future study and development.

基金机构：Chongqing Municipal Education Commission Foundation10.13039/100012494

基金资助正文：No Statement Available