Relationship between triglyceride-glucose index and blood eosinophils among asthmatic individuals in the USA

作者全名：Wen, Jun; Liao, Jiaxin; Wei, Chengcheng; Xia, Jing; Giri, Mohan; Guo, Shuliang

作者地址：[Wen, Jun; Liao, Jiaxin; Giri, Mohan; Guo, Shuliang] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Wei, Chengcheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China; [Wei, Chengcheng] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Urol, Wuhan, Hubei, Peoples R China; [Xia, Jing] Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Chongqing, Peoples R China

通信作者：Guo, SL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China.

来源：LIPIDS IN HEALTH AND DISEASE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001228899800002

JCR分区：Q2

影响因子：3.9

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Triglyceride-glucose index (TyGI); Blood eosinophil count (BEOC); Asthma; Generalized additive model (GAM); Threshold effect; XGBoost

摘要：Background Presently, the majority of investigations primarily evaluate the correlation between triglyceride-glucose index (TyGI) with lung diseases, such as asthma. However, they did not delve into the correlation between TyGI and inflammatory responses related to the disease. Few studies have explored the association between TyGI and blood eosinophil count (BEOC). Thus, National Health and Nutrition Examination Survey (NHANES) data were used in this study to evaluate the correlation between TyGI and BEOC in individuals with asthma.Methods This study investigated 3902 individuals with asthma. Linear regression analysis was performed to investigate the association between TyGI and BEOC in patients with asthma. Subsequently, the GAM and threshold effect models were used to validate the presence of either a nonlinear or linear association between TyGI and BEOC. Finally, stratified analyses were conducted to ascertain the correlations between different subgroups.Results Four linear regression models confirmed a positive linear correlation between TyGI and BEOC in patients with asthma. In Model D, which controlled for all covariates, BEOC increased by 12.44 cells/uL for every extra unit of TyGI. The GAM and threshold effect models further verified the positive linear correlation between TyGI and BEOC. The XGBoost model indicated that the six most significant variables influencing BEOC, in order of relative importance, were age, cholesterol level, body mass index (BMI), poverty-to-income ratio (PIR), BNEUC, and TyGI.Conclusions In patients with asthma, the study discovered a linear positive correlation between TyGI and BEOC. This indicates a potential connection between TyGI and alterations in the immune status of individuals with asthma, which may help detect abnormalities in a timely manner and provide a reference for clinical decision-making. This study offers fresh insights for the future exploration of the management and treatment of asthma.

基金机构：Chongqing Talents, Teachers and Masters

基金资助正文：Not applicable.