Research progress of circRNA as a biomarker of osteoporosis

作者全名：Du, Xing; Chen, Zhongyao; Shui, Wei

作者地址：[Du, Xing; Chen, Zhongyao; Shui, Wei] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing, Peoples R China; [Du, Xing; Chen, Zhongyao; Shui, Wei] Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China

通信作者：Shui, W (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing, Peoples R China.; Shui, W (通讯作者)，Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China.

来源：FRONTIERS IN GENETICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001228997600001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：osteoporosis; biomarkers; osteoblasts; osteoclasts; circRNA

摘要：Osteoporosis, as a chronic metabolic bone disease, has the characteristic of insidious disease progression, which often leads to relatively delayed disease diagnosis. Therefore, early screening for osteoporosis has become a major public health challenge. The latest research indicates that circRNA is widely involved in the regulation of bone metabolism and is closely related to the occurrence and development of osteoporosis. Based on its high degree of sequence conservation and stability, circRNA has the potential to become a new clinical biomarker. The study of biomarkers is generally based on body fluid samples or adjacent tissue samples, with blood being the most commonly used, which can be divided into sources such as serum, plasma, peripheral blood monocytes, and plasma exosomes. Therefore, this article aims to review the research status of circRNA as a biomarker of osteoporosis.

基金机构：Natural Science Foundation of China [81501922]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0781, CSTB2022NSCQ-MSX0972]; Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) [2023QNXM030]

基金资助正文：The authors declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by the Natural Science Foundation of China (81501922), the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0781, CSTB2022NSCQ-MSX0972), and the Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) (2023QNXM030)..