Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-De fi cit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits

作者全名：Verhoef, Ellen; Allegrini, Andrea G.; Jansen, Philip R.; Lange, Katherine; Wang, Carol A.; Morgan, Angela T.; Ahluwalia, Tarunveer S.; Symeonides, Christos; Eising, Else; Franken, Marie-Christine; Hypponen, Elina; Mansell, Toby; Olislagers, Mitchell; Omerovic, Emina; Rimfeld, Kaili; Schlag, Fenja; Selzam, Saskia; Shapland, Chin Yang; Tiemeier, Henning; Whitehouse, Andrew J. O.; Saffery, Richard; Bonnelykke, Klaus; Reilly, Sheena; Pennell, Craig E.; Wake, Melissa; Cecil, Charlotte A. M.; Plomin, Robert; Fisher, Simon E.; St Pourcain, Beate

作者地址：[Verhoef, Ellen; Eising, Else; Olislagers, Mitchell; Schlag, Fenja; Fisher, Simon E.; St Pourcain, Beate] Max Planck Inst Psycholinguist, Language & Genet Dept, Nijmegen, Netherlands; [Allegrini, Andrea G.; Rimfeld, Kaili; Selzam, Saskia; Plomin, Robert] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England; [Jansen, Philip R.; Tiemeier, Henning; Cecil, Charlotte A. M.] Erasmus MC, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands; [Jansen, Philip R.] Vrije Univ, Ctr Neurogenom & Cognit Res, Dept Complex Trait Genet, Amsterdam Neurosci, Amsterdam, Netherlands; [Jansen, Philip R.] Univ Amsterdam, Dept Human Genet, Clin Genet Sect, Med Ctr, Amsterdam, Netherlands; [Lange, Katherine; Morgan, Angela T.; Symeonides, Christos; Mansell, Toby; Omerovic, Emina; Saffery, Richard; Reilly, Sheena; Wake, Melissa] Murdoch Childrens Res Inst, Parkville, Vic, Australia; [Lange, Katherine; Morgan, Angela T.; Mansell, Toby; Saffery, Richard; Reilly, Sheena; Wake, Melissa] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia; [Wang, Carol A.; Pennell, Craig E.] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia; [Wang, Carol A.; Pennell, Craig E.] Hunter Med Res Inst, Mothers & Babies Res Program, Newcastle, NSW, Australia; [Morgan, Angela T.] Univ Melbourne, Dept Audiol & Speech Pathol, Parkville, Vic, Australia; [Morgan, Angela T.; Symeonides, Christos] Royal Childrens Hosp, Melbourne, Vic, Australia; [Ahluwalia, Tarunveer S.; Bonnelykke, Klaus] Univ Copenhagen, Herlev & Gentofte Hosp, Copenhagen Prospective Studies Asthma Childhood, Copenhagen, Denmark; [Ahluwalia, Tarunveer S.] Steno Diabet Ctr Copenhagen, Herlev, Denmark; [Ahluwalia, Tarunveer S.] Univ Copenhagen, Bioinformat Ctr, Dept Biol, Copenhagen, Denmark; [Symeonides, Christos] Minderoo Fdn, Perth, WA, Australia; [Franken, Marie-Christine] Erasmus MC, Sophia Childrens Univ Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Rotterdam, Netherlands; [Hypponen, Elina] Univ South Australia, Australian Ctr Precis Hlth, Unit Clin & Hlth Sci, Adelaide, SA, Australia; [Hypponen, Elina] South Australian Hlth & Med Res Inst, Adelaide, SA, Australia; [Olislagers, Mitchell] Erasmus MC, Inst Canc, Dept Urol, Rotterdam, Netherlands; [Rimfeld, Kaili] Royal Holloway Univ London, Dept Psychol, London, England; [Shapland, Chin Yang; St Pourcain, Beate] Univ Bristol, Med Res Council Integrat Epidemiol Unit, Bristol, Avon, England; [Shapland, Chin Yang] Univ Bristol, Populat Hlth Sci, Bristol, Avon, England; [Tiemeier, Henning] Harvard TH Chan Sch Publ Hlth, Boston, MA USA; [Whitehouse, Andrew J. O.] Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia; [Saffery, Richard] Chongqing Med Univ, Chongqing, Peoples R China; [Reilly, Sheena] Griffith Univ, Menzies Hlth Inst Queensland, Brisbane, Qld, Australia; [Pennell, Craig E.] John Hunter Hosp, Matern & Gynaecol, Newcastle, NSW, Australia; [Wake, Melissa] Univ Auckland, Liggins Inst, Grafton, New Zealand; [Cecil, Charlotte A. M.] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands; [Cecil, Charlotte A. M.] Leiden Univ, Med Ctr, Dept Biomed Data Sci, Mol Epidemiol, Leiden, Netherlands; [Fisher, Simon E.; St Pourcain, Beate] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands

通信作者：Fisher, SE; St Pourcain, B (通讯作者)，Max Planck Inst Psycholinguist, Language & Genet Dept, Nijmegen, Netherlands.; St Pourcain, B (通讯作者)，Univ Bristol, Med Res Council Integrat Epidemiol Unit, Bristol, Avon, England.; Fisher, SE; St Pourcain, B (通讯作者)，Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.

来源：BIOLOGICAL PSYCHIATRY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001229364500001

JCR分区：Q1

影响因子：9.6

年份：2024

卷号：95

期号：9

开始页：859

结束页：869

文献类型：Article

关键词：　

摘要：BACKGROUND: The number of words children produce (expressive vocabulary) and understand (receptive vocabulary) changes rapidly during early development, partially due to genetic factors. Here, we performed a meta- genome-wide association study of vocabulary acquisition and investigated polygenic overlap with literacy, cognition, developmental phenotypes, and neurodevelopmental conditions, including attention-deficit/hyperactivity disorder (ADHD). METHODS: We studied 37,913 parent -reported vocabulary size measures (English, Dutch, Danish) for 17,298 children of European descent. Meta -analyses were performed for early -phase expressive (infancy, 15-18 months), late -phase expressive (toddlerhood, 24-38 months), and late -phase receptive (toddlerhood, 24-38 months) vocabulary. Subsequently, we estimated single nucleotide polymorphism-based heritability (SNP - h 2 ) and genetic correlations ( r g ) and modeled underlying factor structures with multivariate models. RESULTS: Early -life vocabulary size was modestly heritable (SNP - h 2 = 0.08-0.24). Genetic overlap between infant expressive and toddler receptive vocabulary was negligible ( r g = 0.07), although each measure was moderately related to toddler expressive vocabulary ( r g = 0.69 and r g = 0.67, respectively), suggesting a multifactorial genetic architecture. Both infant and toddler expressive vocabulary were genetically linked to literacy (e.g., spelling: r g = 0.58 and r g = 0.79, respectively), underlining genetic similarity. However, a genetic association of early -life vocabulary with educational attainment and intelligence emerged only during toddlerhood (e.g., receptive vocabulary and intelligence: r g = 0.36). Increased ADHD risk was genetically associated with larger infant expressive vocabulary ( r g = 0.23). Multivariate genetic models in the ALSPAC (Avon Longitudinal Study of Parents and Children) cohort confirmed this finding for ADHD symptoms (e.g., at age 13; r g = 0.54) but showed that the association effect reversed for toddler receptive vocabulary ( r g = 20.74), highlighting developmental heterogeneity. CONCLUSIONS: The genetic architecture of early -life vocabulary changes during development, shaping polygenic association patterns with later -life ADHD, literacy, and cognition -related traits.

基金机构：Max Planck Society; Novo Nordisk Foundation [54741]; National Health and Medical Research Council; Australian Government National Health and Medical Research Council Postgraduate Research Scholarship; National Health and Medical Research Council Australia; Australian Research Council; Medical Research Future Fund; Tour de Cure; NWO VICI grant [VI.C.211.054]; Norwegian Diabetes Association [WELL-BEING 771057]; ERC; European Union's Horizon 2020 Research and Innovation Programme; Miguel Servet II fellowship - Spanish Institute of Health Carlos III; MCIN/AEI [MC_UU_00032/02]; Generalitat de Catalunya through the CERCA (Centres de Recerca de Catalunya) Program; UK National Institute for Health Research through the academic clinical fellowship scheme; Sir Henry Wellcome Postdoctoral Fellowship; UK Medical Research Council Integrative Epidemiology Unit at the University of Bristol [273291]; KG Jebsen Stiftelsen,; Research Council of Norway [324252, 262177, 288083, 293574, 848158]; European Research Council (AdG SELECTionPREDISPOSED) [NNF18OC0052457]; Bergen Research Foundation; Stiftelsen Kristian Gerhard Jebsen (Translational Medical Center); University of Bergen; Western Norway Regional Health Authority (Strategic Fund "Personalized Medicine for Children and Adults"); [CEX2018-000806-S]; [223273]

基金资助正文：EV, EE, FS, SEF, and BSP were funded by the Max Planck Society. TSA was supported by the Novo Nordisk Foundation (Grant No. NNF18OC0052457) . ATM is supported by the National Health and Medical Research Council. CS was supported by an Australian Government National Health and Medical Research Council Postgraduate Research Scholarship. EH receives funding from the National Health and Medical Research Council Australia, Australian Research Council, Medical Research Future Fund, and Tour de Cure. MB is funded by an NWO VICI grant (Grant No. VI.C.211.054) and an ERC consolidation grant (WELL-BEING 771057) . MG is funded by a Miguel Servet II fellowship (CPII18/00018) awarded by the Spanish Institute of Health Carlos III. We acknowledge support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033 and support from the Generalitat de Catalunya through the CERCA (Centres de Recerca de Catalunya) Program. SH receives support from the UK National Institute for Health Research through the academic clinical fellowship scheme. KR is supported by a Sir Henry Wellcome Postdoctoral Fellowship. CYS and JLM are supported by the UK Medical Research Council Integrative Epidemiology Unit at the University of Bristol (MC_UU_00032/02) . OAA is supported by KG Jebsen Stiftelsen, Research Council of Norway (Grant No. 223273, 273291, 324252) . EY receives support from Research Council of Norway (Grant Nos. 262177 and 288083) . PRN was supported by grants from the European Research Council (AdG SELECTionPREDISPOSED #293574) , the Bergen Research Foundation ("Utilizing the Mother and Child Cohort and the Medical Birth Registry for Better Health") , Stiftelsen Kristian Gerhard Jebsen (Translational Medical Center) , the University of Bergen, the Western Norway Regional Health Authority (Strategic Fund "Personalized Medicine for Children and Adults") , Novo Nordisk Foundation Grant No. 54741, and the Norwegian Diabetes Association. CAMC receives support from the European Union's Horizon 2020 Research and Innovation Programme (Grant agreement No. 848158) (EarlyCause Project) . BSP, EV, and the EAGLE Working Group report that the EAGLE Working Group is one of thenamed authors and that all members qualify for authorship.