Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study

作者全名：Li, Junyao; Hu, Renqin; Luo, Huirong; Guo, Yanwei; Zhang, Zheng; Luo, Qinghua; Xia, Pingyou

作者地址：[Li, Junyao; Hu, Renqin; Luo, Huirong; Guo, Yanwei; Zhang, Zheng; Luo, Qinghua] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Xia, Pingyou] Yongchuan Dist Mental Hlth Ctr, Chongqing, Peoples R China

通信作者：Luo, QH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China.; Xia, PY (通讯作者)，Yongchuan Dist Mental Hlth Ctr, Chongqing, Peoples R China.

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001229805300001

JCR分区：Q2

影响因子：3.2

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：diet; bipolar disorder; Mendelian randomization; nutrition; prevention

摘要：Background Diet/nutrition is critically important in the pathogenesis, progression, and treatment outcomes of various mental disorders. Current research predominantly focuses on the role of diet in the development and treatment of depression, with less attention given to the relationship between diet and Bipolar Disorder (BD).Method We employed Mendelian Randomization (MR) to investigate the relationship between 28 dietary habits and BD. An analysis was conducted using publicly available genome-wide association study data from the UK Biobank dataset. Various dietary habits were analyzed as exposures with BD as the outcome, mainly using the Inverse Variance Weighted (IVW) method.Results Intake of non-oily fish and sponge pudding both have a positive association with BD. Oily fish, dried fruit, apples, salt, and cooked vegetables intake also appeared potentially risky for BD, although the possibility of false positives cannot be ruled out. Sensitivity analysis further confirmed the robustness of these findings.Conclusion Our research provides evidence of a relationship between various dietary habits and BD. It underscores the need for careful dietary management and balance to reduce the risk of BD, suggesting caution with dietary preferences for fish and sponge pudding. Furthermore, more detailed studies are needed to further understand the potential impacts of high-sugar and high-protein diets on BD development.

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