"Predicting epithelial ovarian cancer prognosis: correlation of posttreatment <SUP>18</SUP>F-fluorodeoxyglucose positron emission tomography-computed tomography metabolic parameters, serum carbohydrate antigen, and human epididymis protein levels with overall survival"

作者全名："Yang, Lu; Li, Mengdan; Liang, Huan; Wang, Xiaohui; Guan, Lili; Jing, Xingguo"

作者地址："[Yang, Lu; Li, Mengdan; Liang, Huan; Wang, Xiaohui; Guan, Lili; Jing, Xingguo] Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, 1 Youyi Rd, Chongqing 400042, Peoples R China"

通信作者："Guan, LL; Jing, XG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, 1 Youyi Rd, Chongqing 400042, Peoples R China."

来源：QUANTITATIVE IMAGING IN MEDICINE AND SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001230196700006

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：14

期号：1

开始页：972

结束页：985

文献类型：Article

关键词：Ovarian cancer (OC); carbohydrate antigen 125 (CA125); human epididymis protein 4 (HE4); positron emission tomography/computed tomography (PET/CT); overall survival (OS)

摘要："Background: Identifying reliable prognostic indicators can aid in improving patient care. The aim of this study was to establish the association of18F-fluorodeoxyglucose positron emission tomography -computed tomography (F-18-FDG PET/CT) whole -body metabolic parameters, serum carbohydrate antigen 125 (CA125), and human epididymis protein 4 (HE4) with overall survival (OS) in patients with epithelial ovarian cancer (EOC) after surgery combined with platinum -based chemotherapy. Methods: From May 2014 to May 2019, a total of 79 patients with EOC who underwent posttreatment 18F-FDG PET/CT in the First Affiliated Hospital of Chongqing Medical University were included. Clinical data and laboratory indicators were obtained. The whole -body maximum standardized uptake value (WBSUVmax), whole -body metabolic tumor volume (WBMTV), and whole -body total lesion glycolysis (WBTLG) were measured and calculated on 18F-FDG PET/CT. The follow-up was conducted until February 2023, and the endpoint was death from any cause. Pearson correlation analysis, Kaplan -Meier, and Cox proportional regression were used in this study. Results: The PET -positive (PET -P) patients had significantly decreased OS based on either Kaplan -Meier survival analysis (P<0.001) or univariate Cox regression analysis [hazard ratio (HR) =40.177, 95% confidence interval (CI): 2.690-600.134; P=0.007]. ""Ln"" is a logarithmic transformation with a base of ""e"" (natural logarithm). LnWBMTV, lnWBTLG, and therapy after PET were independent predictors of OS in a cohort of 63 PET -P patients. The difference in OS between groups sorted by the median WBMTV (4.16; P<0.001) and WBTLG (14.71; P<0.001) was statistically significant. There were statistically significant differences in CA125 and HE4 levels between patients in the PET -P and PET -negative (PET -N) groups (P<0.001). In the PET -P patient cohort, serum HE4 levels were substantially correlated with WBMTV and WBTLG. Kaplan -Meier survival analysis suggested a reduction in OS after treatment in patients with EOC positive for CA125, HE4, and PET (P<0.001). Conclusions: Post-PET/CT treatment strategy, WBMTV, and WBTLG demonstrated significant prognostic utility in predicting posttreatment OS in patients with EOC. Patients who tested positive for both tumor markers CA125 and HE4 and had a positive PET scan demonstrated a significantly poorer prognosis in terms of posttreatment OS."

基金机构：Health Commission Combined Science and Technology Project of Chongqing [2020MSXM066]

基金资助正文：Funding: This work was supported by the Health Commission Combined Science and Technology Project of Chongqing (No. 2020MSXM066) .